Gene
tdo2a
- ID
- ZDB-GENE-030131-1187
- Name
- tryptophan 2,3-dioxygenase a
- Symbol
- tdo2a Nomenclature History
- Previous Names
-
- tdo2
- fb62b10
- wu:fb62b10
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to have heme binding activity and tryptophan 2,3-dioxygenase activity. Predicted to be involved in protein homotetramerization; tryptophan catabolic process to acetyl-CoA; and tryptophan catabolic process to kynurenine. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and familial hypertryptophanemia. Orthologous to human TDO2 (tryptophan 2,3-dioxygenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial hypertryptophanemia | Alliance | [?Hypertryptophanemia] | 600627 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Tryptophan 2,3-dioxygenase | Tryptophan/Indoleamine 2,3-dioxygenase-like |
|---|---|---|---|
|
UniProtKB:A7MBU6
|
406 | ||
|
UniProtKB:A0A8M9QAT4
|
300 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
tdo2a-204
(1)
|
Ensembl | 892 nt | ||
| mRNA |
tdo2a-201
(1)
|
Ensembl | 1,552 nt | ||
| ncRNA |
tdo2a-003
(1)
|
Ensembl | 747 nt | ||
| ncRNA |
tdo2a-004
(1)
|
Ensembl | 965 nt | ||
| ncRNA |
tdo2a-005
(1)
|
Ensembl | 720 nt | ||
| ncRNA |
tdo2a-006
(1)
|
Ensembl | 1,442 nt |
Interactions and Pathways
No data available
Plasmids
No data available