Gene

agrn

ID

ZDB-GENE-030131-1033

Name

agrin

Symbol

agrn Nomenclature History

Previous Names

agrin
hm:gc12
sb:eu553
wu:fb57e07

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have serine-type endopeptidase inhibitor activity. Involved in anterior/posterior pattern specification and nervous system development. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 8. Is expressed in several structures, including immature eye; nervous system; neural tube; notochord; and pronephric duct. Orthologous to human AGRN (agrin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 7 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu553 (13 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 18 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With agrn Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital myasthenic syndrome 8	Alliance	Myasthenic syndrome, congenital, 8, with pre- and postsynaptic defects	615120

Associated With agrn Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000082	SEA domain
Domain	IPR000742	EGF-like domain
Domain	IPR001791	Laminin G domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR002049	Laminin-type EGF domain
Domain	IPR002350	Kazal domain
Domain	IPR003645	Follistatin-like, N-terminal
Domain	IPR003884	Factor I / membrane attack complex
Domain	IPR004850	NtA (N-terminal agrin) domain
Homologous_superfamily	IPR008993	Tissue inhibitor of metalloproteinases-like, OB-fold
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily	IPR036058	Kazal domain superfamily
Homologous_superfamily	IPR036364	SEA domain superfamily

Domain Details Per Protein

Protein	Length	Concanavalin A-like lectin/glucanase domain superfamily	EGF-like calcium-binding domain	EGF-like domain	Factor I / membrane attack complex	Follistatin-like, N-terminal	Kazal domain	Kazal domain superfamily	Laminin G domain	Laminin-type EGF domain	NtA (N-terminal agrin) domain	SEA domain	SEA domain superfamily	Tissue inhibitor of metalloproteinases-like, OB-fold
UniProtKB:B3GQ72 InterPro	2028
UniProtKB:A0A0R4IJ40 InterPro	1926
UniProtKB:A0A8M9PT59 InterPro	1947
UniProtKB:A0A8M9PT52 InterPro	2052
UniProtKB:A0A8M9PWK3 InterPro	1949
UniProtKB:A0A8M9P562 InterPro	2049
UniProtKB:A0A8M9PF41 InterPro	2045
UniProtKB:A0A8M3B648 InterPro	2048
UniProtKB:A0A8M9PKT2 InterPro	2056
UniProtKB:A0A8M3AYE9 InterPro	2033
UniProtKB:A0A8M9P566 InterPro	2029
UniProtKB:A0A8M3ANN0 InterPro	2037
UniProtKB:A0A8M9PWJ8 InterPro	2055
UniProtKB:A0A8M9PKT9 InterPro	1960