Gene
smad7
- ID
- ZDB-GENE-030128-3
- Name
- SMAD family member 7
- Symbol
- smad7 Nomenclature History
- Previous Names
-
- madh7
- fj60c10
- wu:fj60c10
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; I-SMAD binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including cell differentiation; regulation of transcription by RNA polymerase II; and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to localize to cytoplasm and heteromeric SMAD protein complex. Is expressed in several structures, including axis; ectoderm; immature eye; midbrain neural tube; and nervous system. Human ortholog(s) of this gene implicated in colorectal cancer and pancreatic adenocarcinoma. Orthologous to human SMAD7 (SMAD family member 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77461 (1 image)
- eu607 (20 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Colorectal cancer, susceptibility to, 3} | 612229 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001132 | SMAD domain, Dwarfin-type |
| Domain | IPR003619 | MAD homology 1, Dwarfin-type |
| Domain | IPR013019 | MAD homology, MH1 |
| Family | IPR013790 | Dwarfin |
| Homologous_superfamily | IPR008984 | SMAD/FHA domain superfamily |
| Homologous_superfamily | IPR017855 | SMAD-like domain superfamily |
| Homologous_superfamily | IPR036578 | SMAD MH1 domain superfamily |
Domain Details Per Protein
| Protein | Length | Dwarfin | MAD homology 1, Dwarfin-type | MAD homology, MH1 | SMAD domain, Dwarfin-type | SMAD/FHA domain superfamily | SMAD-like domain superfamily | SMAD MH1 domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6NZT3
|
372 |
Interactions and Pathways
Plasmids
No data available