Gene
lyz
- ID
- ZDB-GENE-020515-2
- Name
- lysozyme
- Symbol
- lyz Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable lysozyme activity. Involved in cell maturation. Is expressed in several structures, including cardiovascular system; hematopoietic cell; hematopoietic system; mesoderm; and pleuroperitoneal region. Orthologous to several human genes including LYZL1 (lysozyme like 1) and LYZL2 (lysozyme like 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 145 figures from 99 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Amyloidosis, hereditary systemic 5 | 620658 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Glycoside hydrolase, family 22 | Glycoside hydrolase family 22 domain | Glycoside hydrolase, family 22, lysozyme | Lysozyme-like domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:Q90YS5
|
151 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(lyz:DsRed2) |
|
| 1 | (238) | |
| Tg(lyz:EGFP) |
|
| 1 | (120) | |
| Tg(-2.4lyz:EGFP) |
|
| 4 | (8) | |
| Tg2(lyz:EGFP) |
|
| 1 | Gao et al., 2018 | |
| Tg(-4.1lyz:EGFP) |
|
| 1 | (21) | |
| Tg(lyz:akt2-EGFP) |
|
| 1 | (5) | |
| Tg(lyz:BFP) |
|
| 1 | (8) | |
| Tg(lyz:Cas9-CRISPR1-mfn2-CRISPR2-mfn2-CRISPR3-mfn2-CRISPR4-mfn2) |
|
| 1 | (2) | |
| Tg(lyz:Cas9-CRISPR1-opa1-CRISPR2-opa1) |
|
| 1 | (2) | |
| Tg(lyz:Cas9-CRISPR2-mfn2) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-80N22 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136734 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194008 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_139180 (1) | 596 nt | ||
| Genomic | GenBank:CT574587 (1) | 160942 nt | ||
| Polypeptide | UniProtKB:Q90YS5 (1) | 151 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | LYZ | 12 | Amino acid sequence comparison (2) |
- Belt, A.J., Grant, S., Tombes, R.M., Rothschild, S.C. (2024) Myeloid Targeted Human MLL-ENL and MLL-AF9 Induces cdk9 and bcl2 Expression in Zebrafish Embryos. PLoS Genetics. 20:e1011308e1011308
- Carey, C.M., Hollins, H.L., Schmid, A.V., Gagnon, J.A. (2024) Distinct features of the regenerating heart uncovered through comparative single-cell profiling. Biology Open. 13(4):
- Doll, L., Welte, K., Skokowa, J., Bajoghli, B. (2024) A JAGN1-associated severe congenital neutropenia zebrafish model revealed an altered G-CSFR signaling and UPR activation. Blood advances. 8(15):4050-4065
- Han, Y., Sun, K., Yu, S., Qin, Y., Zhang, Z., Luo, J., Hu, H., Dai, L., Cui, M., Jiang, C., Liu, F., Huang, Y., Gao, P., Chen, X., Xin, T., Ren, X., Wu, X., Song, J., Wang, Q., Tang, Z., Chen, J., Zhang, H., Zhang, X., Liu, M., Luo, D. (2024) A Mettl16/m6A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells. The EMBO journal. 43(10):1990-2014
- Isiaku, A.I., Zhang, Z., Pazhakh, V., Lieschke, G.J. (2024) A nox2/cybb zebrafish mutant with defective myeloid cell reactive oxygen species production displays normal initial neutrophil recruitment to sterile tail injuries. G3 (Bethesda). 14(6):
- Jia-Xin, H., Song'en, X., Wen-Qing, Z., Wei, L. (2024) The interaction of Pu.1 and cMyb in zebrafish neutrophil development. Yi chuan = Hereditas. 46:319332319-332
- Lints, R., Walker, C.A., Delfi, O., Prouse, M., De Silva, M.P., Bohlander, S.K., Wood, A.C. (2024) Mutational cooperativity of RUNX1::RUNX1T1 isoform 9a and oncogenic NRAS in zebrafish myeloid leukaemia. Biology Open. 13(9):
- Lv, Y., Li, J., Yu, S., Zhang, Y., Hu, H., Sun, K., Jia, D., Han, Y., Tu, J., Huang, Y., Liu, X., Zhang, X., Gao, P., Chen, X., Shaw Williams, M.T., Tang, Z., Shu, X., Liu, M., Ren, X. (2024) The splicing factor Prpf31 is required for hematopoietic stem and progenitor cell expansion during zebrafish embryogenesis. The Journal of biological chemistry. 300(3):105772
- Xu, Y., Guo, R., Huang, T., Guo, C. (2024) miRNA-7145-cuedc2 axis controls hematopoiesis through JAK1/STAT3 signaling pathway. Cell death discovery. 10:209209
- Bu, L.K., Jia, P.P., Li, W.G., Li, Y.Z., Li, T.Y., Pei, D.S. (2023) Probiotics mitigate kidney damage after exposure to Sri Lanka's local groundwater from chronic kidney disease with uncertain etiology (CKDu) prevalent area in zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 262:106671106671
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