Gene

tfe3b

ID

ZDB-GENE-010919-3

Name

transcription factor binding to IGHM enhancer 3b

Symbol

tfe3b Nomenclature History

Previous Names

si:dkey-13a21.9

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to have protein dimerization activity. Predicted to be involved in humoral immune response; positive regulation of transcription, DNA-templated; and regulation of osteoclast differentiation. Human ortholog(s) of this gene implicated in renal cell carcinoma. Is expressed in several structures, including digestive system; ionocyte; lens placode; polster; and sensory system. Orthologous to human TFE3 (transcription factor binding to IGHM enhancer 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu646 (2 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tfe3b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
renal cell carcinoma	Alliance	Renal cell carcinoma, papillary, 1	300854
		Intellectual developmental disorder, X-linked syndromic, with pigmentary mosaicism and coarse facies	301066

Associated With tfe3b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Domain	IPR021802	MiT/TFE transcription factors, C-terminal
Domain	IPR024100	Transcription factor E3, bHLHzip domain
Domain	IPR031867	MiT/TFE transcription factors, N-terminal
Homologous_superfamily	IPR036638	Helix-loop-helix DNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	Helix-loop-helix DNA-binding domain superfamily	MiT/TFE transcription factors, C-terminal	MiT/TFE transcription factors, N-terminal	Myc-type, basic helix-loop-helix (bHLH) domain	Transcription factor E3, bHLHzip domain
UniProtKB:A0A8M2BGM5 InterPro	445
UniProtKB:F1R1N1 InterPro	451
UniProtKB:A0A8M6Z8P2 InterPro	294
UniProtKB:Q7SZX8 InterPro	451
UniProtKB:A0A8M2BGP5 InterPro	449
UniProtKB:A0A8M3B427 InterPro	447
UniProtKB:A0A8M2BH69 InterPro	443