Gene
ache
- ID
- ZDB-GENE-010906-1
- Name
- acetylcholinesterase (Yt blood group)
- Symbol
- ache Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Exhibits acetylcholinesterase activity. Involved in several processes, including acetylcholine catabolic process; cellular response to methanol; and response to amphetamine. Predicted to localize to several cellular components, including cell junction; extracellular region; and synapse. Human ortholog(s) of this gene implicated in Alzheimer's disease; epilepsy; and myasthenia gravis. Is expressed in several structures, including female organism; male organism; myotome; nervous system; and neural tube. Orthologous to human ACHE (acetylcholinesterase (Cartwright blood group)).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 29 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu3 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 23 figures from 10 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
[Blood group, Yt system] | 112100 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR019826 | Carboxylesterase type B, active site |
Conserved_site | IPR019819 | Carboxylesterase type B, conserved site |
Domain | IPR002018 | Carboxylesterase, type B |
Domain | IPR014788 | Acetylcholinesterase, tetramerisation domain |
Family | IPR000997 | Cholinesterase |
Family | IPR050654 | Acetylcholinesterase-related enzymes |
Homologous_superfamily | IPR029058 | Alpha/Beta hydrolase fold |
Domain Details Per Protein
Protein | Length | Acetylcholinesterase-related enzymes | Acetylcholinesterase, tetramerisation domain | Alpha/Beta hydrolase fold | Carboxylesterase, type B | Carboxylesterase type B, active site | Carboxylesterase type B, conserved site | Cholinesterase |
---|---|---|---|---|---|---|---|---|
UniProtKB:B3DKL4
|
634 | |||||||
UniProtKB:Q9DDE3
|
634 |
Interactions and Pathways
No data available
Plasmids
No data available