Gene
copb2
- ID
- ZDB-GENE-010724-7
- Name
- COPI coat complex subunit beta 2
- Symbol
- copb2 Nomenclature History
- Previous Names
-
- dop
- dopey
- sb:cb121
- wu:fb30f06
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable structural molecule activity. Acts upstream of or within several processes, including Golgi localization; endoplasmic reticulum localization; and notochord development. Predicted to be located in Golgi membrane and cytoplasmic vesicle. Predicted to be part of COPI vesicle coat. Is expressed in several structures, including axial mesoderm; cardiovascular system; digestive system; fin; and nervous system. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 19. Orthologous to human COPB2 (COPI coat complex subunit beta 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb121 (18 images)
Wild Type Expression Summary
- All Phenotype Data
- 19 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary autosomal recessive microcephaly 19 | Alliance | ?Microcephaly 19, primary, autosomal recessive | 617800 |
| Osteoporosis, childhood- or juvenile-onset, with developmental delay | 619884 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR016453 | Coatomer beta' subunit (COPB2) |
| Family | IPR050844 | Coatomer complex subunit |
| Homologous_superfamily | IPR011044 | Quinoprotein amine dehydrogenase, beta chain-like |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
| Repeat | IPR020472 | G-protein beta WD-40 repeat |
Domain Details Per Protein
| Protein | Length | Coatomer beta' subunit (COPB2) | Coatomer complex subunit | G-protein beta WD-40 repeat | Quinoprotein amine dehydrogenase, beta chain-like | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6JWU7
|
934 |
Interactions and Pathways
No data available
Plasmids
No data available