Gene

mapk8b

ID
ZDB-GENE-010202-1
Name
mitogen-activated protein kinase 8b
Symbol
mapk8b Nomenclature History
Previous Names
  • jnk1 (1)
  • jnk1b (1)
  • JNK (1)
  • mapk8
  • jnk1a-1 (1)
  • zgc:112379
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to have JUN kinase activity. Involved in JNK cascade and determination of dorsal identity. Predicted to localize to cytoplasm; nucleus; and synapse. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; benign rectal neoplasm; colorectal adenoma; and type 2 diabetes mellitus. Is expressed in brain; gut; and pectoral fin. Orthologous to human MAPK8 (mitogen-activated protein kinase 8).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
16 figures from 12 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mapk8b Human Ortholog
No data available
Associated With mapk8b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Conserved_site IPR003527 Mitogen-activated protein (MAP) kinase, conserved site
Domain IPR000719 Protein kinase domain
Family IPR008351 Mitogen-activated protein (MAP) kinase, JNK
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Mitogen-activated protein (MAP) kinase, conserved site Mitogen-activated protein (MAP) kinase, JNK Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:E9QB50
UniProtKB:E9QJ67
UniProtKB:F1RCB7
UniProtKB:Q9DGD9 384
UniProtKB:A0A8M6Z1Z5 428
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations