Gene

sox5

ID

ZDB-GENE-000607-13

Name

SRY-box transcription factor 5

Symbol

sox5 Nomenclature History

Previous Names

sox5b (1)
id:ibd5067
sb:eu456
si:dkey-215a8.1

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to have DNA binding activity. Involved in iridophore differentiation; melanocyte differentiation; and xanthophore differentiation. Predicted to localize to nucleus. Is expressed in several structures, including central nervous system; digestive system; fin; forebrain neural keel; and gonad. Orthologous to human SOX5 (SRY-box transcription factor 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

17 figures from 9 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu456 (14 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Nagao et al., 2018
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sox5 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Lamb-Shaffer syndrome	616803

Associated With sox5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR009071	High mobility group box domain
Family	IPR051356	SOX/SOX-like transcription factors
Homologous_superfamily	IPR036910	High mobility group box domain superfamily

Domain Details Per Protein

Protein	Length	High mobility group box domain	High mobility group box domain superfamily	SOX/SOX-like transcription factors
UniProtKB:A0A8M9Q0P1 InterPro	735
UniProtKB:A0A8M9PUN3 InterPro	759
UniProtKB:A0A8M2BBY9 InterPro	731
UniProtKB:A0A8M2BC41 InterPro	758
UniProtKB:Q3ZM07 InterPro	759
UniProtKB:A0A8M9QBE2 InterPro	762
UniProtKB:A0A8M9Q0N4 InterPro	763