Gene

pycard

ID

ZDB-GENE-000511-2

Name

PYD and CARD domain containing

Symbol

pycard Nomenclature History

Previous Names

apoptosis-associated speck-like protein containing a CARD
asc1 (1)
ASC (1)
zAsc (1)
zgc:109874

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Exhibits Pyrin domain binding activity. Involved in defense response to bacterium; innate immune response; and positive regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to localize to cytoplasm. Is expressed in several structures, including digestive system; immune system; integument; periderm; and unfertilized egg. Orthologous to human PYCARD (PYD and CARD domain containing).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

21 figures from 10 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:109874 (8 images)
eu1007 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pycard Human Ortholog

No data available

Associated With pycard Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001315	CARD domain
Domain	IPR004020	DAPIN domain
Domain	IPR033516	CARD8/ASC/NALP1, CARD domain
Homologous_superfamily	IPR011029	Death-like domain superfamily