Gene
meis2b
- ID
- ZDB-GENE-000210-23
- Name
- Meis homeobox 2b
- Symbol
- meis2b Nomenclature History
- Previous Names
-
- meis2.1
- meis2
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have DNA binding activity. Involved in cardiac atrium morphogenesis and heart looping. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in ceft palate, cardiac defects, and intellectual disabillity. Is expressed in several structures, including anterior neural keel; heart rudiment; nervous system; neural plate; and pericardial region. Orthologous to human MEIS2 (Meis homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:76815 (20 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cleft palate, cardiac defects, and intellectual disabillity | Alliance | Cleft palate, cardiac defects, and impaired intellectual development | 600987 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homeobox domain | Homeobox KN domain | Homeobox-like domain superfamily | Homeobox protein PKNOX/Meis, N-terminal |
|---|---|---|---|---|---|
|
UniProtKB:Q9DDE0
|
|||||
|
UniProtKB:Q9PTM7
|
393 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
meis2b-203
(1)
|
Havana | 3104 nt | |
| ncRNA |
meis2b-002
(1)
|
Havana | 843 nt |
Interactions and Pathways
No data available
Plasmids
No data available