PUBLICATION
Preliminary Results Regarding Sleep in a Zebrafish Model of Autism Spectrum Disorder
- Authors
- Robea, M.A., Ciobica, A., Curpan, A.S., Plavan, G., Strungaru, S., Lefter, R., Nicoara, M.
- ID
- ZDB-PUB-210501-35
- Date
- 2021
- Source
- Brain sciences 11(5): (Journal)
- Registered Authors
- Keywords
- aggression, autism spectrum disorder, sleep, social behavior, zebrafish larvae
- MeSH Terms
- none
- PubMed
- 33924776 Full text @ Brain Sci
Citation
Robea, M.A., Ciobica, A., Curpan, A.S., Plavan, G., Strungaru, S., Lefter, R., Nicoara, M. (2021) Preliminary Results Regarding Sleep in a Zebrafish Model of Autism Spectrum Disorder. Brain sciences. 11(5).
Abstract
Autism spectrum disorder (ASD) is one of the most salient developmental neurological diseases and remarkable similarities have been found between humans and model animals of ASD. A common method of inducing ASD in zebrafish is by administrating valproic acid (VPA), which is an antiepileptic drug that is strongly linked with developmental defects in children. In the present study we replicated and extended the findings of VPA on social behavior in zebrafish by adding several sleep observations. Juvenile zebrafish manifested hyperactivity and an increase in ASD-like social behaviors but, interestingly, only exhibited minimal alterations in sleep. Our study confirmed that VPA can generate specific ASD symptoms, indicating that the zebrafish is an alternative model in this field of research.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping