PUBLICATION
The zinc finger protein Zfpm1 modulates ventricular trabeculation through Neuregulin-ErbB signalling
- Authors
- Yang, Y., Li, B., Zhang, X., Zhao, Q., Lou, X.
- ID
- ZDB-PUB-190107-1
- Date
- 2019
- Source
- Developmental Biology 446(2): 142-150 (Journal)
- Registered Authors
- Li, Beibei, Lou, Xin, Yang, Yuxi
- Keywords
- Neuregulin-ERBB signalling, heart development, ventricle trabeculation, zebrafish, zfpm1
- Datasets
- GEO:GSE95118
- MeSH Terms
-
- Gene Expression Regulation, Developmental
- Neuregulins/genetics*
- Neuregulins/metabolism
- Myocardium/cytology
- Myocardium/metabolism*
- Gene Expression Profiling
- Myocytes, Cardiac/cytology
- Myocytes, Cardiac/metabolism
- Cell Proliferation/genetics
- Zebrafish Proteins/genetics*
- Zebrafish Proteins/metabolism
- Microscopy, Confocal
- Signal Transduction/genetics*
- Heart/embryology
- Receptor, ErbB-2/genetics*
- Receptor, ErbB-2/metabolism
- Zebrafish/embryology
- Zebrafish/genetics
- Zebrafish/metabolism
- Cells, Cultured
- Animals, Genetically Modified
- Animals
- Gene Knockout Techniques
- PubMed
- 30611731 Full text @ Dev. Biol.
Citation
Yang, Y., Li, B., Zhang, X., Zhao, Q., Lou, X. (2019) The zinc finger protein Zfpm1 modulates ventricular trabeculation through Neuregulin-ErbB signalling. Developmental Biology. 446(2):142-150.
Abstract
Ventricular trabeculation is one essential step for generating a functionally competent ventricular wall, while how the early trabeculae carneae forms and subsequently develops into mature chambers is poorly understood. We found that in zebrafish zfpm1-/- juvenile, cardiac function is significantly compromised, with hearts exhibiting deformed trabecular meshwork. To elucidate the mechanisms of Zfpm1 function in cardiac trabeculation, we analyzed zfpm1 mutant hearts more closely and found that loss of Zfpm1 activity resulted in over-activation of Neuregulin-ErbB signaling and abnormally elevated cardiomyocyte proliferation during cardiac trabeculae growth and modeling stages. These results implicate Zfpm1 plays a pivotal role in coordinating trabeculae patterning and growth.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping