PUBLICATION
Acteoside protects against 6-OHDA-induced dopaminergic neuron damage via Nrf2-ARE signaling pathway
- Authors
- Li, M., Zhou, F., Xu, T., Song, H., Lu, B.
- ID
- ZDB-PUB-180616-11
- Date
- 2018
- Source
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 119: 6-13 (Journal)
- Registered Authors
- Keywords
- Acteoside, Nrf2, Parkinson's disease, The blood-brain-barrier, Zebrafish
- MeSH Terms
-
- Animals
- Antioxidants/metabolism
- Carboxylic Ester Hydrolases/genetics
- Carboxylic Ester Hydrolases/metabolism*
- Dopaminergic Neurons/drug effects*
- Gene Expression Regulation, Enzymologic/drug effects
- Glucosides/pharmacology*
- Larva
- Malondialdehyde/metabolism
- Metabolic Networks and Pathways/drug effects
- Motor Activity/drug effects
- NF-E2-Related Factor 2/genetics
- NF-E2-Related Factor 2/metabolism*
- Oxidopamine/toxicity*
- Phenols/pharmacology*
- Zebrafish
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism*
- PubMed
- 29906474 Full text @ Food Chem. Toxicol.
- CTD
- 29906474
Citation
Li, M., Zhou, F., Xu, T., Song, H., Lu, B. (2018) Acteoside protects against 6-OHDA-induced dopaminergic neuron damage via Nrf2-ARE signaling pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 119:6-13.
Abstract
Acteoside has been reported to have antioxidant and neuroprotective effect, which is a promising therapeutic way in prevention and treatment of Parkinson's disease. The present study was aimed to understand the neuroprotective effect of acteoside and to elucidate its underlying mechanism. 6-hydroxydopamine (6-OHDA)-induced neural damage in zebrafish model was used to study the protective effect of acteoside on Parkinson disease (PD). Locomotion behavioral test showed that acteoside could prevent 6-OHDA-stimulated movement disorders. Anti-tyrosine hydroxylase (TH) whole-mount immunostaining analysis showed that acteoside could prevent 6-OHDA-induced dopaminergic neuron death. In addition, pretreatment with acteoside could upregulate antioxidative enzymes by activating the Nrf2/ARE signaling pathway in zebrafish. Meanwhile, acteoside was found to be distributed in the brain after intraperitoneal injection into the adult zebrafish, indicating that this compound could penetrate the blood-brain-barrier (BBB). This study demonstrated that acteoside could penetrate BBB and have potential therapeutic value for Parkinson's disease by activating the Nrf2/ARE signaling pathway and attenuating the oxidative stress.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping