PUBLICATION
Environmentally Relevant Concentrations of the Flame Retardant Tris(1,3-dichloro-2-propyl) Phosphate (TDCIPP) Inhibits Growth of Female Zebrafish and Decreases Fecundity
- Authors
- Zhu, Y., Ma, X., Su, G., Yu, L., Letcher, R.J., Hou, J., Yu, H., Giesy, J.P., Liu, C.
- ID
- ZDB-PUB-151030-5
- Date
- 2015
- Source
- Environmental science & technology 49(24): 14579-87 (Journal)
- Registered Authors
- Zhu, Ya
- Keywords
- none
- MeSH Terms
-
- Animals
- Down-Regulation
- Female
- Fertility/drug effects*
- Flame Retardants/administration & dosage
- Flame Retardants/pharmacokinetics
- Flame Retardants/toxicity*
- Gene Expression Regulation/drug effects
- Gonads/drug effects
- Liver/drug effects
- Liver/metabolism
- Male
- Organophosphates
- Organophosphorus Compounds/administration & dosage
- Organophosphorus Compounds/pharmacokinetics
- Organophosphorus Compounds/toxicity*
- Ovum/drug effects
- Reproduction/drug effects
- Testosterone/analogs & derivatives
- Testosterone/blood
- Tissue Distribution
- Toxicity Tests, Chronic
- Water Pollutants, Chemical/administration & dosage
- Water Pollutants, Chemical/pharmacokinetics
- Water Pollutants, Chemical/toxicity*
- Zebrafish/growth & development
- Zebrafish/physiology
- PubMed
- 26512412 Full text @ Env. Sci. Tech.
- CTD
- 26512412
Citation
Zhu, Y., Ma, X., Su, G., Yu, L., Letcher, R.J., Hou, J., Yu, H., Giesy, J.P., Liu, C. (2015) Environmentally Relevant Concentrations of the Flame Retardant Tris(1,3-dichloro-2-propyl) Phosphate (TDCIPP) Inhibits Growth of Female Zebrafish and Decreases Fecundity. Environmental science & technology. 49(24):14579-87.
Abstract
Bioconcentration of tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) in brain, gonad and liver as well as effects on fecundity and development of zebrafish (Danio rerio) were determined. Zebrafish (1-month old) were exposed to environmentally relevant concentrations of 29 ± 2.1, 600 ± 21 or 6300 ± 130 ng TDCIPP/L. After 120 days of exposure, TDCIPP accumulated in the brain, gonad and liver with bioconcentration factors of 460, 38 and 87 in females and 26, 55 and 110 in males, respectively. TDCIPP accumulated to a greater extent in brains of females than those of males. Exposure to 6300 ± 130 ng TDCIPP/L resulted in significantly (P < 0.05) fewer eggs being produced, but histology of the gonad, plasma concentrations of estradiol and 11-ketotestosterone, and expression of genes involved in hypothalamic-pituitary-gonadal-liver axis were not significantly (P > 0.05) different between individuals exposed to TDCIPP and the unexposed control fish. Exposure to TDCIPP resulted in shorter body length, lighter body mass and lesser Gonado-Somatic Index in females. These effects were possibly due to down-regulation of expression of genes along the growth hormone/insulin-like growth factor (GH/IGF) axis. Correlations between the production of eggs and developmental parameters or expression of genes along the GH/IGF axis further suggested that environmentally relevant concentrations of TDCIPP could have adverse effects on reproduction, possibly due to the inhibition of the growth of females.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping