PUBLICATION
Whole-brain activity maps reveal stereotyped, distributed networks for visuomotor behavior
- Authors
- Portugues, R., Feierstein, C.E., Engert, F., Orger, M.B.
- ID
- ZDB-PUB-140513-305
- Date
- 2014
- Source
- Neuron 81: 1328-43 (Journal)
- Registered Authors
- Engert, Florian
- Keywords
- none
- MeSH Terms
-
- Neuroimaging/methods
- Behavior, Animal/physiology*
- Neurons/physiology*
- Brain Mapping
- Brain/physiology*
- Animals
- Nerve Net/physiology*
- Zebrafish/physiology*
- PubMed
- 24656252 Full text @ Neuron
Citation
Portugues, R., Feierstein, C.E., Engert, F., Orger, M.B. (2014) Whole-brain activity maps reveal stereotyped, distributed networks for visuomotor behavior. Neuron. 81:1328-43.
Abstract
Most behaviors, even simple innate reflexes, are mediated by circuits of neurons spanning areas throughout the brain. However, in most cases, the distribution and dynamics of firing patterns of these neurons during behavior are not known. We imaged activity, with cellular resolution, throughout the whole brains of zebrafish performing the optokinetic response. We found a sparse, broadly distributed network that has an elaborate but ordered pattern, with a bilaterally symmetrical organization. Activity patterns fell into distinct clusters reflecting sensory and motor processing. By correlating neuronal responses with an array of sensory and motor variables, we find that the network can be clearly divided into distinct functional modules. Comparing aligned data from multiple fish, we find that the spatiotemporal activity dynamics and functional organization are highly stereotyped across individuals. These experiments systematically reveal the functional architecture of neural circuits underlying a sensorimotor behavior in a vertebrate brain.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping