PUBLICATION
Marine Cyclotripeptide X-13 Promotes Angiogenesis in Zebrafish and Human Endothelial Cells via PI3K/Akt/eNOS Signaling Pathways
- Authors
- Lu, X.L., Xu, Z.L., Yao, X.L., Su, F.J., Ye, C.H., Li, J., Lin, Y.C., Wang, G.L., Zeng, J.S., Huang, R.X., Ou, J.S., Sun, H.S., Wang, L.P., Pang, J.Y., and Pei, Z.
- ID
- ZDB-PUB-120724-34
- Date
- 2012
- Source
- Marine drugs 10(6): 1307-1320 (Journal)
- Registered Authors
- Keywords
- angiogenesis, marine cyclotripeptide, zebrafish, endothelial nitric oxide synthase, xyloallenoide A
- MeSH Terms
-
- Chromones/pharmacology
- Proto-Oncogene Proteins c-akt/antagonists & inhibitors
- Proto-Oncogene Proteins c-akt/metabolism*
- Animals
- Fungi/chemistry
- Nitric Oxide Synthase Type III/antagonists & inhibitors
- Nitric Oxide Synthase Type III/metabolism*
- Cell Line
- NG-Nitroarginine Methyl Ester/pharmacology
- Morpholines/pharmacology
- Biological Products/chemical synthesis
- Biological Products/chemistry
- Biological Products/isolation & purification
- Biological Products/pharmacology
- Aquatic Organisms/chemistry*
- Phosphorylation/drug effects
- Angiogenesis Inducing Agents/chemical synthesis
- Angiogenesis Inducing Agents/chemistry
- Angiogenesis Inducing Agents/isolation & purification
- Angiogenesis Inducing Agents/pharmacology*
- Humans
- Endothelial Cells/drug effects
- Endothelial Cells/metabolism
- Nitric Oxide/metabolism
- Zebrafish/metabolism
- Phosphatidylinositol 3-Kinases/antagonists & inhibitors
- Phosphatidylinositol 3-Kinases/metabolism*
- Human Umbilical Vein Endothelial Cells
- Neovascularization, Physiologic/drug effects*
- Signal Transduction/drug effects*
- PubMed
- 22822374 Full text @ Mar. Drugs
Citation
Lu, X.L., Xu, Z.L., Yao, X.L., Su, F.J., Ye, C.H., Li, J., Lin, Y.C., Wang, G.L., Zeng, J.S., Huang, R.X., Ou, J.S., Sun, H.S., Wang, L.P., Pang, J.Y., and Pei, Z. (2012) Marine Cyclotripeptide X-13 Promotes Angiogenesis in Zebrafish and Human Endothelial Cells via PI3K/Akt/eNOS Signaling Pathways. Marine drugs. 10(6):1307-1320.
Abstract
Cyclotripeptide X-13 is a core of novel marine compound xyloallenoide A isolated from mangrove fungus Xylaria sp. (no. 2508). We found that X-13 dose-dependently induced angiogenesis in zebrafish embryos and in human endothelial cells, which was accompanied by increased phosphorylation of eNOS and Akt and NO release. Inhibition of PI3K/Akt/eNOS by LY294002 or L-NAME suppressed X-13-induced angiogenesis. The present work demonstrates that X-13 promotes angiogenesis via PI3K/Akt/eNOS pathways.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping