PUBLICATION

In Vivo Migration: A Germ Cell Perspective

Authors
Kunwar, P.S., Siekhaus, D.E., and Lehmann, R.
ID
ZDB-PUB-060623-4
Date
2006
Source
Annual Review of Cell and Developmental Biology   22: 237-265 (Journal)
Registered Authors
Keywords
none
MeSH Terms
  • Animals
  • Cell Movement*
  • Drosophila/cytology
  • Germ Cells/cytology*
  • Mice
  • Zebrafish/physiology
PubMed
16774460 Full text @ Annu. Rev. Cell Dev. Biol.
Abstract
The basic concepts of the molecular machinery that mediates cell migration have been gleaned from cell culture systems. However, the three-dimensional environment within an organism presents migrating cells with a much greater challenge. They must move between and among other cells while interpreting multiple attractive and repulsive cues to choose their proper path. They must coordinate their cell adhesion with their surroundings and know when to start and stop moving. New insights into the control of these remaining mysteries have emerged from genetic dissection and live imaging of germ cell migration in Drosophila, zebrafish, and mouse embryos. In this review, we first describe germ cell migration in cellular and mechanistic detail in these different model systems. We then compare these systems to highlight the emerging principles. Finally, we contrast the migration of germ cells with that of immune and cancer cells to outline the conserved and different mechanisms.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping