PUBLICATION

Notch signaling: endocytosis makes delta signal better

Authors
Le Borgne, R. and Schweisguth, F.
ID
ZDB-PUB-030408-6
Date
2003
Source
Current biology : CB   13(7): R273-275 (Review)
Registered Authors
Keywords
none
MeSH Terms
  • Animals
  • Endocytosis/genetics
  • Endocytosis/physiology*
  • Gene Expression Regulation/genetics
  • Gene Expression Regulation/physiology*
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins/genetics*
  • Membrane Proteins/metabolism*
  • Receptors, Cell Surface/metabolism*
  • Receptors, Notch
  • Signal Transduction
  • Ubiquitin-Protein Ligases/metabolism
  • Xenopus
  • Zebrafish
  • Zebrafish Proteins/metabolism
PubMed
12676105 Full text @ Curr. Biol.
Abstract
Endocytosis of cell surface receptors is involved in down-regulation of receptor activity. Recent findings indicate that, paradoxically, endocytosis of a membrane-spanning ligand may up-regulate receptor activity: the zebrafish E3 ligase Mind bomb promotes the endocytosis of Delta and is required for efficient activation of Notch.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping