PUBLICATION
CHK2 kinase--a busy messenger
- Authors
- Bartek, J., Falck, J., and Lukas, J.
- ID
- ZDB-PUB-080801-20
- Date
- 2001
- Source
- Nature reviews. Molecular cell biology 2(12): 877-886 (Review)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Biological Evolution
- Cell Cycle
- Checkpoint Kinase 2
- Drug Design
- Enzyme Activation
- Enzyme Inhibitors/pharmacology
- Genes, Tumor Suppressor
- Humans
- Models, Biological
- Mutation
- Neoplasms/genetics
- Protein Kinases/chemistry
- Protein Kinases/genetics
- Protein Kinases/physiology*
- Protein Serine-Threonine Kinases*
- Signal Transduction
- PubMed
- 11733767 Full text @ Nat. Rev. Mol. Cell. Biol.
Citation
Bartek, J., Falck, J., and Lukas, J. (2001) CHK2 kinase--a busy messenger. Nature reviews. Molecular cell biology. 2(12):877-886.
Abstract
Checkpoint kinase 2 (Chk2) is emerging as a key mediator of diverse cellular responses to genotoxic stress, guarding the integrity of the genome throughout eukaryotic evolution. Recent studies show the fundamental role of Chk2 in the network of genome-surveillance pathways that coordinate cell-cycle progression with DNA repair and cell survival or death. Defects in Chk2 contribute to the development of both hereditary and sporadic human cancers, and earmark this kinase as a candidate tumour suppressor and an attractive target for drug discovery.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping