ZFIN All Figures, Ramšak <i>et al.</i>, 2022

Ramšak et al., 2022

ZDB-PUB-220318-5
PMID:35295214
FIGURE 1
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FIGURE SUMMARY

Title: From Causal Networks to Adverse Outcome Pathways: A Developmental Neurotoxicity Case Study
Authors: Ramšak, Ž., Modic, V., Li, R.A., Vom Berg, C., Zupanic, A.
Source: Full text @ Front Toxicol

FIGURE 1

FIGURE 1. Schematic diagram of the network preparation procedure. First, the BEL network (A) is converted into its abstract form (B). This simplification results in the formation of self-loops (protein-D), which are removed together with all nodes that do not lead to a pathology node (C).

FIGURE 2

NTOX network. (A) The reduced NTOX network (125 nodes, 212 connections) where the start nodes are enzymes (red) and the final node is microphthalmos (purple). All other nodes that are part of the candidate AOPs are marked in yellow. (B) The subnetwork of the candidate AOPs that end with microphthalmos. The two candidate AOPs that were further developed into AOPs are marked in green (AOP 399) and blue (AOP 410).

FIGURE 3

AOP 399. Inhibition of Fyna leads to increased mortality via decreased eye size (microphthalmos).

FIGURE 4

Linear path which we developed into AOP 410 and its connection to otic vesicle formation node before removing non-pathology-ends. Yellow nodes represent linear path upstream of cell death.

FIGURE 5

AOP 410. Gsk3beta inactivation leads to increased mortality via defects in development of the inner ear.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Toxicol

Ramšak et al., 2022 ZDB-PUB-220318-5 PMID:35295214

From Causal Networks to Adverse Outcome Pathways: A Developmental Neurotoxicity Case Study

Ramšak et al., 2022

ZDB-PUB-220318-5
PMID:35295214