- Title
-
Variations of enzymatic activity and gene expression in zebrafish (Danio rerio) embryos co-exposed to zearalenone and fumonisin B1
- Authors
- Yang, G., Wang, Y., Wang, T., Wang, D., Weng, H., Wang, Q., Chen, C.
- Source
- Full text @ Ecotoxicol. Environ. Saf.
The oxidative reactions of fish embryos administrated with ZEN, FB1 and their combinations. Data are presented as the means ± standard deviation of three triplicates. *p < 0.05, substantial alteration by comparison with the control; # p < 0.05, substantial alteration by comparison with the ZEN administration group at counterpart concentration; ☆p < 0.05, substantial alteration by comparison with the FB1 administration group at counterpart concentration. ZEN = zearalenone; FB1 = fumonisin B1; L = low concentration; M = middle concentration; H = high concentration. |
The apoptotic and detoxification enzyme activities, thyroid hormones and VTG levels of fish embryos administrated with ZEN, FB1 and their combinations. Data are presented as the means ± standard deviation of three triplicates. *p < 0.05, substantial alteration by comparison with the control; # p < 0.05, substantial alteration by comparison with the ZEN administration group at counterpart concentration; ☆p < 0.05, substantial alteration by comparison with the FB1 administration group at counterpart concentration. ZEN = zearalenone; FB1 = fumonisin B1; L = low concentration; M = middle concentration; H = high concentration. |
Integrated biomarker response index of all indicators for zebrafish embryos after exposure to ZEN (A), FB1 (B) and their combinations (C). The length from original point of the star plot to the crossover point of the different color circle and the coordinate axis represents standardized value of each index at different concentration. The black circle is a base line. ZEN = zearalenone; FB1 = fumonisin B1; L = low concentration; M = middle concentration; H = high concentration. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) |
Influences on transcription levels of genes associated with the anti-oxidative systems and cell apoptosis of fish embryos administrated with ZEN, FB1 and their combinations. Data are presented as the means ± standard deviation of three triplicates. *p < 0.05, substantial alteration by comparison with the control; # p < 0.05, substantial alteration by comparison with the ZEN administration group at counterpart concentration; ☆p < 0.05, substantial alteration by comparison with the FB1 administration group at counterpart concentration. ZEN = zearalenone; FB1 = fumonisin B1; L = low concentration; M = middle concentration; H = high concentration. |
Influences on transcription levels of genes associated with immunology system, HPT, HPG and HPA axes of fish embryos administrated with ZEN, FB1 and their combinations. Data are presented as the means ± standard deviation of three triplicates. *p < 0.05, substantial alteration by comparison with the control; # p < 0.05, substantial alteration by comparison with the ZEN administration group at counterpart concentration; ☆p < 0.05, substantial alteration by comparison with the FB1 administration group at counterpart concentration. ZEN = zearalenone; FB1 = fumonisin B1; L = low concentration; M = middle concentration; H = high concentration. |
Heat map evaluation for analyzing throughout variations of mRNA expression. ZEN = zearalenone; FB1 = fumonisin B1; L = low concentration; M = middle concentration; H = high concentration; COT = ZEN +FB1 mixture. |