FIGURE SUMMARY
Title

Phyllolobium chinense Fisch Flavonoids (PCFF) Suppresses the M1 Polarization of LPS-Stimulated RAW264.7 Macrophages by Inhibiting NF-κB/iNOS Signaling Pathway

Authors
Fan, H., Wu, Q., Peng, L., Li, D., Dong, Y., Cao, M., Liu, P., Wang, X., Hu, X., Wang, Y.
Source
Full text @ Front Pharmacol
Figure 1

High Performance Liquid Chromatography of PCFF. (A) complanatosides B reference substance; (B) complanatosides A reference substance; (C) Sample.
Figure 2

Survival rate of zebrafish. Each value indicates the mean ± SD from three independent experiments. Compared with normal group, *P < 0.05, **P < 0.01.
Figure 3

Inhibitory effect of PCFF on migration of zebrafish macrophages and neutrophils. Each value indicates the mean ± SD from three independent experiments. Compared with normal group, ##P < 0.01; compared with control group, **P < 0.01. NC group untreated; Model group cut tail; PCFF group added different dose PCFF after tail cut.
Figure 4

Inhibitory effect of PCFF on expression of iNOS、TNF-α and IL-1β mRNA. Each value indicates the mean ± SD from three independent experiments. Compared with normal group, ##P < 0.01; compared with control group, *P < 0.05, **P < 0.01. NC group untreated; Model group cut tail; PCFF group added different dose PCFF after cut tail.
Figure 5

Cytotoxicity of PCFF on RAW264.7 cells and effects of PCFF on LPS-induced NO production in RAW264.7 cells. (A) Each value indicates the mean ± SD from three independent experiments. Compared with untreated group, **P <0.01; (B) Compared with NC group, ##P < 0.01; compared with LPS group, **P <0.01.
Figure 6

Effect of PCFF on LPS-induced inflammatory factor iNOS gene in RAW264.7 cells. Each value indicates the mean ± SD from three independent experiments. Compared with NC group, ##P <0.01; compared with LPS group, **P <0.01.
Figure 7

Effects of PCFF on TNF-alpha secretion in LPS-induced RAW264.7 cells. Each value indicates the mean ± SD from three independent experiments. Compared with NC group, ##P < 0.01.
Figure 8

Effects of PCFF on NF-κB and MAPK signaling pathway proteins in LPS-stimulated RAW264.7 macrophages. (A) Effect of PCFF on p65 and iNOS proteins; (B) Effect of PCFF on JNK, P38 and iNOS proteins; (C) Effect of PCFF on ERK1/2 and iNOS proteins. Each value indicates the mean ± SD from three independent experiments. Compared with NC group, ##P < 0.01; compared with LPS group, **P < 0.01.
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Pharmacol
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