- Title
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A new perspective on fungal metabolites: identification of bioactive compounds from fungi using zebrafish embryogenesis as read-out
- Authors
- Hoeksma, J., Misset, T., Wever, C., Kemmink, J., Kruijtzer, J., Versluis, K., Liskamp, R.M.J., Boons, G.J., Heck, A.J.R., Boekhout, T., den Hertog, J.
- Source
- Full text @ Sci. Rep.
Fungal secondary metabolite mixtures induced distinct morphological defects in zebrafish embryos. Zebrafish embryos were incubated with fungal secondary metabolite mixtures from 6 hpf onwards. Embryos were imaged at 48 hpf. ( |
Identification of fusaric acid as bioactive compound from |
Reduced body axis extension phenotypes induced by commercially available compounds. Embryos were treated with compounds from 6 hpf onwards and were imaged at 48 hpf. |
A dilution range reveals specific effects of compactin and verrucarin A on zebrafish embryogenesis. Zebrafish embryos were treated with different concentrations of ( |
Craniofacial defects in embryos of the “shorter” category. Reduced body axis extension may be due to defects in convergence and extension cell movements, which is accompanied by craniofacial defects. Alcian blue staining was performed and the cartilage was imaged laterally and dorsally to illustrate ( |