- Title
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Sirtuin 1 and Autophagy Attenuate Cisplatin-Induced Hair Cell Death in the Mouse Cochlea and Zebrafish Lateral Line
- Authors
- Pang, J., Xiong, H., Zhan, T., Cheng, G., Jia, H., Ye, Y., Su, Z., Chen, H., Lin, H., Lai, L., Ou, Y., Xu, Y., Chen, S., Huang, Q., Liang, M., Cai, Y., Zhang, X., Xu, X., Zheng, Y., Yang, H.
- Source
- Full text @ Front. Cell. Neurosci.
Autophagy activation promotes hair cell survival after cisplatin-induced damage in zebrafish lateral line. (A) Hair cell counts obtained from CDDP exposure for 12 or 24 h with or without RA or SRT1720 treatment (n = 6 zebrafish larvae). Scale bar, 10 μm. (B) The hair cells were counted at 12 h after CDDP exposure. (C) The hair cells were counted 24 h after CDDP exposure. Data represent the mean ± SEM. ***p < 0.001. Control, zebrafish larvae cultured in the same dose DMSO as the CDDP and RA group; RA, zebrafish larvae cultured in RA; CDDP, zebrafish larvae cultured in CDDP; pre-RA+CDDP, zebrafish larvae cultured in RA for 1 h followed by exposure to CDDP; RA + CDDP, zebrafish larvae cultured in CDDP and RA. SRT1720, zebrafish larvae cultured in SRT1720; pre-SRT1720+CDDP, zebrafish larvae cultured in SRT1720 for 1 h followed by exposure to CDDP; SRT1720 + CDDP, zebrafish larvae cultured in CDDP and SRT1720. CDDP, cisplatin; RA, rapamycin; SRT, SRT1720. |