Head cartilage structures of alcian blue-stained zebrafish embryos in ventral and lateral views after exposure to DMSO only (solvent control), cyproconazole (60 µM), flusilazole (10 µM), metam (10 µM) or thiram (0.3 µM), at the highest non-lethal concentrations. The first row shows a schematic representation of the head skeleton, reproduced with permission from Kimmel et al. (1998). M Meckel’s cartilage, PQ palatoquadrate cartilage, CH ceratohyal cartilage (see Kimmel et al. 1998 for explanation of other structures)

Concentration–response curves for cyproconazole and metam on several quantitative parameters. The Y-axis shows the response (in µm or degrees) and the X-axis the concentration (log10 µM). All graphs are exponentially modeled: y = a × [c − (c − 1)exp(− bx^d)], with a, background, b, sensitivity, c, maximal effect, d, slope. Small symbols, individual observations; triangles, mean values per concentration group; dotted line, BMC at 5%. a PQ–PQ distance; b M–M distance; c PQ length; d M–CH distance; e PQ–PQ/M–M ratio; f M–CH angle; g CH angle; h PQ–CH angle; i M angle