- Title
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CMTM4 regulates angiogenesis by promoting cell surface recycling of VE-cadherin to endothelial adherens junctions
- Authors
- Chrifi, I., Louzao-Martinez, L., Brandt, M.M., van Dijk, C.G.M., Bürgisser, P.E., Zhu, C., Kros, J.M., Verhaar, M.C., Duncker, D.J., Cheng, C.
- Source
- Full text @ Angiogenesis
Morpholino silencing of CMTM4 in developing zebrafish larvae induces defects in intersomitic vessels. a Tg(fli1:eGFP)y1 larvae at 24 h post fertilization, anterior to the right, lateral view. Defects in intersomitic vessel (ISV) formation was observed in the trunk region in specimens injected with morpholinos targeting the splice site of i2-e3 of CMTM4 (indicated as i2-e3 CMTM4) compared with uninjected (UI) controls. The vasculature is highlighted by eGFP (green). Left-hand panels show ×2 magnification images with 0.5 mm scale bar, right-hand panels show 10x images with 0.25 mm scale bar. b Quantification of ISV defect phenotype versus wildtype (WT) phenotype in i2-e3 injected group at different doses versus UI controls (UIC). Data represent percentage of counted larvae (~ 100 per group)
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