FIGURE SUMMARY
- Title
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Overexpression of EZH2 in conjunctival melanoma offers a new therapeutic target
- Authors
- Cao, J., Pontes, K.C.S., Heijkants, R.C., Brouwer, N.J., Groenewoud, A., Jordanova, E.S., Marinkovic, M., van Duinen, S., Teunisse, A.F.A.S., Verdijk, R.M., Snaar-Jagalska, E., Jochemsen, A.G., Jager, M.J.
- Source
- Full text @ J. Pathol.
GSK503 suppresses the growth of CM cell lines in a zebrafish model. CM cells were labelled with tomato red (red) and injected into the duct of Cuvier at 2 dpf in (fli:GFP) Casper zebrafish embryos, which have a green vasculature. The images were taken at 6 dpi. (A, black) Representative stereo fluorescent images (original magnification: 20 ×) show inhibition of tumour growth after exposure to 24 μm GSK503. (B, black) Number of red pixels represent tumour cells with DMSO or GSK503 treatment in CM xenografts. Each point indicates one embryo and its corresponding pixel count. Statistical significance was calculated by the generalized linear model and P values are indicated as follows: *p < 0.05, **p < 0.01. NCRMM1/DMSO = 30, NCRMM1/GSK503 = 22, NCRMM2/DMSO = 28, NCRMM2/GSK503 = 23, NCM2005.1/DMSO = 25, NCM2005.1/GSK503 = 18.
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Full text @ J. Pathol.