- Title
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Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point
- Authors
- Baeyens, N., Nicoli, S., Coon, B.G., Ross, T.D., Van den Dries, K., Han, J., Lauridsen, H.M., Mejean, C.O., Eichmann, A., Thomas, J.L., Humphrey, J.D., Schwartz, M.A.
- Source
- Full text @ Elife
Representative pictures of the dorsal aorta (DA), posterior cardinal vein (PCV) and thoracic duct (white *) at 72 hr post-fertilization (hpf) in wild type zebrafish embryos or embryos injected with Flt4 (VEGFR3) morpholino at 0.06 or 0.1 mM, or with VEGF-C morpholino at 0.06 or 0.1 mM. The mCherry reporter driven by the KDR (VEGFR2) promoter (kdrl:mCherry) is depicted in red and the citrine reporter driven by the Flt4 promoter (flt4:citrine) is depicted in green. Scale = 20 µm and applies to all pictures. n = 6-15 fishes for each condition, whiskers represents the minimum and maximum data point (NS: non-significant, ***: p < 0.001 and ****: p < 0.0001, ANOVA). |
Representative pictures of the dorsal aorta (DA) and posterior cardinal vein (PCV) and developing thoracic duct (*) in wild type zebrafish embryos with a citrine reporter associated to Flt4 promoter (flt4:citrine) before and approximatively 2 hr after nifedipine treatment. |