ZFIN ID: ZDB-LAB-980203-1
Byrnes Lab
PI/Director: Byrnes, Lucy
Co-PI / Senior
Researcher:		 Grealy, Maura
Contact Person: Byrnes, Lucy
Email: lucy.byrnes@nuigalway.ie
URL: http://www.nuigalway.ie/biochemistry/staff/byrnes/index.html
Address: Biochemistry School of Natural Sciences National University of Ireland, Galway University Road Galway, Ireland
Country: Ireland
Phone: 353-91-492416
Fax: 353-91-525700
Line Designation: None assigned


GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available


STATEMENT OF RESEARCH INTERESTS
Our current research interests lie in the following areas:

1. Molecular and cellular events at the midblastula transition in zebrafish.

2. The role of IGF signalling during embryonic development, using zebrafish as a model species.


LAB MEMBERS
Hartnett, Lori Graduate Student Martin, Denise Graduate Student McCarthy, Karena Graduate Student
Moriarty, Miriam Graduate Student O'Boyle, Shaun Graduate Student Ryan, Rebecca Graduate Student
Walsh, Melissa Graduate Student Glynn, Catherine Research Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Spelat, R., Ferro, F., Contessotto, P., Aljaabary, A., Martin-Saldaña, S., Jin, C., Karlsson, N.G., Grealy, M., Hilscher, M.M., Magni, F., Chinello, C., Kilcoyne, M., Pandit, A. (2022) Metabolic reprogramming and membrane glycan remodeling as potential drivers of zebrafish heart regeneration. Communications biology. 5:13651365
Zielińska, K.A., Grealy, M., Dockery, P. (2020) A stereological study of developmental changes in hepatocyte ultrastructure of zebrafish (Danio rerio). Journal of anatomy. 236(6):996-1003
Cronin, A., Grealy, M. (2017) Neuroprotective and neuro-restorative effects of minocycline and rasagiline in a zebrafish 6-hydroxydopamine model of Parkinson's disease. Neuroscience. 367:34-46
Fitzgerald, C., Gallagher, E., O'Connor, P., Prieto, J., Mora-Soler, L., Grealy, M., and Hayes, M. (2013) Development of a seaweed derived platelet activating factor acetylhydrolase (PAF-AH) inhibitory hydrolysate, synthesis of inhibitory peptides and assessment of their toxicity using the Zebrafish larvae assay. Peptides. 50C:119-124
Cunningham, S., Brennan-Fournet, M.E., Ledwith, D., Byrnes, L., and Joshi, L. (2013) Effect of nanoparticle stabilisation and physicochemical properties on exposure outcome: Acute toxicity of silver nanoparticle preparations in zebrafish (Danio rerio). Environmental science & technology. 47(8):3883-92
Moriarty, M.A., Ryan, R., Lalor, P., Dockery, P., Byrnes, L., and Grealy, M. (2012) Loss of plakophilin 2 disrupts heart development in zebrafish. The International journal of developmental biology. 56(9):711-718
Hartnett, L., Glynn, C., Nolan, C.M., Grealy, M., and Byrnes, L. (2010) Insulin-like growth factor-2 regulates early neural and cardiovascular system development in zebrafish embryos. The International journal of developmental biology. 54(4):573-583
Tsalavouta, M., Astudillo, O., Byrnes, L., and Nolan, C.M. (2009) Regulation of expression of zebrafish (Danio rerio) insulin-like growth factor 2 receptor: implications for evolution at the IGF2R locus. Evolution & development. 11(5):546-558
Martin, E.D., Moriarty, M.A., Byrnes, L., and Grealy, M. (2009) Plakoglobin has both structural and signalling roles in zebrafish development. Developmental Biology. 327(1):83-96
Moriarty, M.A., Martin, E.D., Byrnes, L., and Grealy, M. (2008) Molecular cloning and developmental expression of plakophilin 2 in zebrafish. Biochemical and Biophysical Research Communications. 367(1):124-129
O'Boyle, S., Bree, R.T., McLoughlin, S., Grealy, M., and Byrnes, L. (2007) Identification of zygotic genes expressed at the midblastula transition in zebrafish. Biochemical and Biophysical Research Communications. 358(2):462-468
Nolan, C.M., McCarthy, K., Eivers, E., Jirtle, R.L., and Byrnes, L. (2006) Mannose 6-phosphate receptors in an ancient vertebrate, zebrafish. Development genes and evolution. 216(3):144-151
Bree, R.T., McLoughlin, S., Jin, S.W., McMeel, O.M., Stainier, D.Y., Grealy, M., and Byrnes, L. (2005) nanor, a novel zygotic gene, is expressed initially at the midblastula transition in zebrafish. Biochemical and Biophysical Research Communications. 333(3):722-728
Eivers, E., McCarthy, K., Glynn, C., Nolan, C.M., and Byrnes, L. (2004) Insulin-like growth factor (IGF) signalling is required for early dorso-anterior development of the zebrafish embryo. The International journal of developmental biology. 48(10):1131-1140
Ayaso, E., Nolan, C.M., and Byrnes, L. (2002) Zebrafish insulin-like growth factor-I receptor: molecular cloning and developmental expression. Molecular and Cellular Endocrinology. 191(2):137-148
Brabazon, E.D., Bree, R.T., Carton, M.W., Grealy, M., and Byrnes, L. (2002) Cyclin-dependent kinase 8 is expressed both maternally and zygotically during zebrafish embryo development. BBA Gene Structure and Expression. 1576(1-2):203-208
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