ZFIN ID: ZDB-LAB-971209-4
Nüsslein-Volhard Lab
PI/Director: Nüsslein-Volhard, Christiane
Co-PI / Senior
Researcher:
Irion, Uwe
Contact Person: Irion, Uwe
Email: uwe.irion@tuebingen.mpg.de
URL: http://www.eb.tuebingen.mpg.de/departments/3-genetics/department-3-genetics
Address: Department 3 - Genetics Max-Planck-Institut für Entwicklungsbiologie Spemannstrasse 35 D-72076 Tübingen GERMANY
Phone: 49-7071-601466
Fax: 49-7071-601384
Line Designation: t


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show first 50 of 2,481 genomic features


STATEMENT OF RESEARCH INTERESTS
Developmental genetics of the zebrafish.

The central focus of the Nüsslein-Volhard fish group is the identification and characterization of genes that play important roles in the development of the zebrafish.

In 1993 the lab performed a large scale mutagenesis screen which resulted in the identification of approximately 1,000 mutants affecting a large variety of processes such as early development, organ formation, simple behaviour and - in collaboration with the group of F. Bonhoeffer (MPI für Entwicklungsbiologie) - axonal pathfinding (Haffter et al., 1996a). Recently, the lab also performed screens for maternal effect mutations and begun to investigate the development of the germ line. Projects in the laboratory currently include the development of neural crest derivatives, early development as well as the formation of muscles, skin, macrophages and the eye.

At the start of 2000, the Nüsslein-Volhard Lab initiated a new large-scale mutagenesis experiment as a joint-venture with Exelixis Deutschland (formerly Artemis), a Tübingen-based pharmaceuticals company. In this screen, scientists from the Nüsslein-Volhard Lab screened for mutations of their particular interest, using histological methods or molecular probes where necessary.

From 2004 - 2006 another big ENU Screen took place as a workpackage of the EU funded project zf models.

The Tübingen Zebrafish Stockcenter is headed by Hans Georg Frohnhöfer- a service facility which maintains mutant and wildtype lines of zebrafish mainly from the first Tübingen screen. These lines are freely available for research.


LAB MEMBERS
Fadeev, Andrey Post-Doc Frohnhöfer, Hans Georg Post-Doc


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS x
Nüsslein-Volhard, C., Singh, A.P. (2017) How fish color their skin: A paradigm for development and evolution of adult patterns: Multipotency, plasticity, and cell competition regulate proliferation and spreading of pigment cells in Zebrafish coloration. BioEssays : news and reviews in molecular, cellular and developmental biology.
Mahalwar, P., Singh, A.P., Fadeev, A., Nüsslein-Volhard, C., Irion, U. (2016) Heterotypic interactions regulate cell shape and density during color pattern formation in zebrafish. Biology Open. 5(11):1680-1690
Singh, A.P., Dinwiddie, A., Mahalwar, P., Schach, U., Linker, C., Irion, U., Nüsslein-Volhard, C. (2016) Pigment Cell Progenitors in Zebrafish Remain Multipotent through Metamorphosis. Developmental Cell. 38(3):316-30
Frohnhöfer, H.G., Geiger-Rudolph, S., Pattky, M., Meixner, M., Huhn, C., Maischein, H.M., Geisler, R., Gehring, I., Maderspacher, F., Nüsslein-Volhard, C., Irion, U. (2016) Spermidine, but not spermine, is essential for pigment pattern formation in zebrafish. Biology Open. 5(6):736-44
Fadeev, A. (2016) The role of tight junction protein 1a and leukocyte tyrosine kinase in the development and organisation of pigment cells in the zebrafish. Ph.D. Thesis.
Fadeev, A., Krauss, J., Singh, A.P., Nüsslein-Volhard, C. (2016) Zebrafish leukocyte tyrosine kinase controls iridophore establishment, proliferation and survival. Pigment cell & melanoma research. 29(3):284-96
Fadeev, A., Krauss, J., Frohnhöfer, H.G., Irion, U., Nüsslein-Volhard, C. (2015) Tight junction protein 1a regulates pigment cell organisation during zebrafish colour patterning. eLIFE. 4
Singh, A.P., Nüsslein-Volhard, C. (2015) Zebrafish Stripes as a Model for Vertebrate Colour Pattern Formation. Current biology : CB. 25:R81-R92
Irion, U., Frohnhöfer, H.G., Krauss, J., Çolak Champollion, T., Maischein, H., Geiger-Rudolph, S., Weiler, C., Nüsslein-Volhard, C. (2014) Gap junctions composed of connexions 41.8 and 39.4 are essential for colour pattern formation in zebrafish. eLIFE. 4:1225-38
Irion, U., Krauss, J., Nüsslein-Volhard, C. (2014) Precise and efficient genome editing in zebrafish using the CRISPR/Cas9 system. Development (Cambridge, England). 141(24):4827-30
Mahalwar, P., Walderich, B., Singh, A.P., Nüsslein-Volhard, C. (2014) Local reorganization of xanthophores fine-tunes and colors the striped pattern of zebrafish. Science (New York, N.Y.). 345:1362-4
Krauss, J., Geiger-Rudolph, S., Koch, I., Nüsslein-Volhard, C., Irion, U. (2014) A dominant mutation in tyrp1A leads to melanophore death in zebrafish. Pigment cell & melanoma research. 27(5):827-30
Krauss, J., Frohnhöfer, H.G., Walderich, B., Maischein, H.M., Weiler, C., Irion, U., Nüsslein-Volhard, C. (2014) Endothelin signalling in iridophore development and stripe pattern formation of zebrafish. Biology Open. 3(6):503-9
Singh, A.P., Schach, U., Nüsslein-Volhard, C. (2014) Proliferation, dispersal and patterned aggregation of iridophores in the skin prefigure striped colouration of zebrafish. Nature Cell Biology. 16(6):607-14
Wang, L., Mongera, A., Bonanomi, D., Cyganek, L., Pfaff, S.L., Nüsslein-Volhard, C., Marquardt, T. (2014) A conserved axon type hierarchy governing peripheral nerve assembly. Development (Cambridge, England). 141:1875-83
Perathoner, S., Daane, J.M., Henrion, U., Seebohm, G., Higdon, C.W., Johnson, S.L., Nüsslein-Volhard, C., and Harris, M.P. (2014) Bioelectric signaling regulates size in zebrafish fins. PLoS Genetics. 10(1):e1004080
Frohnhöfer, H.G., Krauss, J., Maischein, H.M., and Nüsslein-Volhard, C. (2013) Iridophores and their interactions with other chromatophores are required for stripe formation in zebrafish. Development (Cambridge, England). 140(14):2997-3007
Krauss, J., Astrinidis, P., Frohnhöfer, H.G., Walderich, B., and Nüsslein-Volhard, C. (2013) transparent, a gene affecting stripe formation in Zebrafish, encodes the mitochondrial protein Mpv17 that is required for iridophore survival. Biology Open. 2(7):703-710
Mongera, A., and Nüsslein-Volhard, C. (2013) Scales of fish arise from mesoderm. Current biology : CB. 23(9):R338-339
Howe, K., Clark, M.D., Torroja, C.F., Torrance, J., Berthelot, C., Muffato, M., Collins, J.E., Humphray, S., McLaren, K., Matthews, L., McLaren, S., Sealy, I., Caccamo, M., Churcher, C., Scott, C., Barrett, J.C., Koch, R., Rauch, G.J., White, S., Chow, W., Kilian, B., Quintais, L.T., Guerra-Assunção, J.A., Zhou, Y., Gu, Y., Yen, J., Vogel, J.H., Eyre, T., Redmond, S., Banerjee, R., Chi, J., Fu, B., Langley, E., Maguire, S.F., Laird, G.K., Lloyd, D., Kenyon, E., Donaldson, S., Sehra, H., Almeida-King, J., Loveland, J., Trevanion, S., Jones, M., Quail, M., Willey, D., Hunt, A., Burton, J., Sims, S., McLay, K., Plumb, B., Davis, J., Clee, C., Oliver, K., Clark, R., Riddle, C., Eliott, D., Threadgold, G., Harden, G., Ware, D., Mortimer, B., Kerry, G., Heath, P., Phillimore, B., Tracey, A., Corby, N., Dunn, M., Johnson, C., Wood, J., Clark, S., Pelan, S., Griffiths, G., Smith, M., Glithero, R., Howden, P., Barker, N., Stevens, C., Harley, J., Holt, K., Panagiotidis, G., Lovell, J., Beasley, H., Henderson, C., Gordon, D., Auger, K., Wright, D., Collins, J., Raisen, C., Dyer, L., Leung, K., Robertson, L., Ambridge, K., Leongamornlert, D., McGuire, S., Gilderthorp, R., Griffiths, C., Manthravadi, D., Nichol, S., Barker, G., Whitehead, S., Kay, M., Brown, J., Murnane, C., Gray, E., Humphries, M., Sycamore, N., Barker, D., Saunders, D., Wallis, J., Babbage, A., Hammond, S., Mashreghi-Mohammadi, M., Barr, L., Martin, S., Wray, P., Ellington, A., Matthews, N., Ellwood, M., Woodmansey, R., Clark, G., Cooper, J., Tromans, A., Grafham, D., Skuce, C., Pandian, R., Andrews, R., Harrison, E., Kimberley, A., Garnett, J., Fosker, N., Hall, R., Garner, P., Kelly, D., Bird, C., Palmer, S., Gehring, I., Berger, A., Dooley, C.M., Ersan-Ürün, Z., Eser, C., Geiger, H., Geisler, M., Karotki, L., Kirn, A., Konantz, J., Konantz, M., Oberländer, M., Rudolph-Geiger, S., Teucke, M., Osoegawa, K., Zhu, B., Rapp, A., Widaa, S., Langford, C., Yang, F., Carter, N.P., Harrow, J., Ning, Z., Herrero, J., Searle, S.M., Enright, A., Geisler, R., Plasterk, R.H., Lee, C., Westerfield, M., de Jong, P.J., Zon, L.I., Postlethwait, J.H., Nüsslein-Volhard, C., Hubbard, T.J., Crollius, H.R., Rogers, J., and Stemple, D.L. (2013) The zebrafish reference genome sequence and its relationship to the human genome. Nature. 496:498-503
Dooley, C.M., Mongera, A., Walderich, B., and Nüsslein-Volhard, C. (2013) On the embryonic origin of adult melanophores: the role of ErbB and Kit signalling in establishing melanophore stem cells in zebrafish. Development (Cambridge, England). 140(5):1003-1013
Dooley, C.M., Schwarz, H., Mueller, K.P., Mongera, A., Konantz, M., Neuhauss, S.C., Nüsslein-Volhard, C., and Geisler, R. (2013) Slc45a2 and V-ATPase are regulators of melanosomal pH homeostasis in zebrafish, providing a mechanism for human pigment evolution and disease. Pigment cell & melanoma research. 26(2):205-217
Mongera, A., Singh, A.P., Levesque, M.P., Chen, Y.Y., Konstantinidis, P., and Nüsslein-Volhard, C. (2013) Genetic lineage labeling in zebrafish uncovers novel neural crest contributions to the head, including gill pillar cells. Development (Cambridge, England). 140(4):916-925
Chen, Y.Y., Harris, M.P., Levesque, M.P., Nüsslein-Volhard, C., and Sonawane, M. (2012) Heterogeneity across the dorso-ventral axis in zebrafish EVL is regulated by a novel module consisting of sox, snail1a and max genes. Mechanisms of Development. 129(1-4):13-23
Rohner, N., Perathoner, S., Frohnhöfer, H.G., and Harris, M.P. (2011) Enhancing the Efficiency of N-Ethyl-N-Nitrosourea-Induced Mutagenesis in the Zebrafish. Zebrafish. 8(3):119-23
Saito, K., Siegfried, K.R., Nüsslein-Volhard, C., and Sakai, N. (2011) Isolation and cytogenetic characterization of zebrafish meiotic prophase I mutants. Developmental dynamics : an official publication of the American Association of Anatomists. 240(7):1779-92
Reischauer, S., Levesque, M.P., Nüsslein-Volhard, C., and Sonawane, M. (2009) Lgl2 executes its function as a tumor suppressor by regulating ErbB signaling in the zebrafish epidermis. PLoS Genetics. 5(11):e1000720
Rohner, N., Bercsényi, M., Orbán, L., Kolanczyk, M.E., Linke, D., Brand, M., Nüsslein-Volhard, C., and Harris, M.P. (2009) Duplication of fgfr1 Permits Fgf Signaling to Serve as a Target for Selection during Domestication. Current biology : CB. 19(19):1642-1647
Sonawane, M., Martin-Maischein, H., Schwarz, H., and Nüsslein-Volhard, C. (2009) Lgl2 and E-cadherin act antagonistically to regulate hemidesmosome formation during epidermal development in zebrafish. Development (Cambridge, England). 136(8):1231-1240
Rojas-Muñoz, A., Rajadhyksha, S., Gilmour, D., van Bebber, F., Antos, C., Rodríguez Esteban, C., Nüsslein-Volhard, C., and Izpisúa Belmonte, J.C. (2009) ErbB2 and ErbB3 regulate amputation-induced proliferation and migration during vertebrate regeneration. Developmental Biology. 327(1):177-190
Kizil, C., Otto, G.W., Geisler, R., Nüsslein-Volhard, C., and Antos, C.L. (2009) Simplet controls cell proliferation and gene transcription during zebrafish caudal fin regeneration. Developmental Biology. 325(2):329-340
Siegfried, K.R., and Nüsslein-Volhard, C. (2008) Germ line control of female sex determination in zebrafish. Developmental Biology. 324(2):277-287
Harris, M.P., Rohner, N., Schwarz, H., Perathoner, S., Konstantinidis, P., and Nüsslein-Volhard, C. (2008) Zebrafish eda and edar mutants reveal conserved and ancestral roles of ectodysplasin signaling in vertebrates. PLoS Genetics. 4(10):e1000206
Peri, F., and Nüsslein-Volhard, C. (2008) Live Imaging of Neuronal Degradation by Microglia Reveals a Role for v0-ATPase a1 in Phagosomal Fusion In Vivo. Cell. 133(5):916-927
Geisler, R., Rauch, G.J., Geiger-Rudolph, S., Albrecht, A., van Bebber, F., Berger, A., Busch-Nentwich, E., Dahm, R., Dekens, M.P., Dooley, C., Elli, A.F.,Gehring, I., Geiger, H., Geisler, M., Glaser, S., Holley, S., Huber, M., Kerr, A., Kirn, A., Knirsch, M., Konantz, M., Kuchler, A.M., Maderspacher, F., Neuhauss, S.C., Nicolson, T., Ober, E.A., Praeg, E., Ray, R., Rentzsch, B., Rick, J.M., Rief, E., Schauerte, H.E., Schepp, C.P., Schonberger, U., Schonthaler, H.B., Seiler, C., Sidi, S., Söllner, C., Wehner, A., Weiler, C., Nüsslein-Volhard, C. (2007) Large-scale mapping of mutations affecting zebrafish development. BMC Genomics. 8(1):11
Dahm, R., Geisler, R., and Nüsslein-Volhard, C. (2006) Zebrafish (Danio rerio) Genome and Genetics. Encyclopedia of Molecular Cell Biology and Molecular Medicine, 2nd Edition. 15:593-626
Rojas-Munoz, A., Dahm, R., and Nüsslein-Volhard, C. (2005) chokh/rx3 specifies the retinal pigment epithelium fate independently of eye morphogenesis. Developmental Biology. 288(2):348-362
Sonawane, M., Carpio, Y., Geisler, R., Schwarz, H., Maischein, H.M., and Nuesslein-Volhard, C. (2005) Zebrafish penner/lethal giant larvae 2 functions in hemidesmosome formation, maintenance of cellular morphology and growth regulation in the developing basal epidermis. Development (Cambridge, England). 132(14):3255-3265
Lee, J.S., von der Hardt, S., Rusch, M.A., Stringer, S.E., Stickney, H.L., Talbot, W.S., Geisler, R., Nüsslein-Volhard, C., Selleck, S.B., Chien, C.B., and Roehl, H. (2004) Axon Sorting in the Optic Tract Requires HSPG Synthesis by ext2 (dackel) and extl3 (boxer). Neuron. 44(6):947-960
Pelegri, F., Dekens, M.P., Schulte-Merker, S., Maischein, H.M., Weiler, C., and Nüsslein-Volhard, C. (2004) Identification of recessive maternal-effect mutations in the zebrafish using a gynogenesis-based method. Developmental dynamics : an official publication of the American Association of Anatomists. 231(2):324-335
Gilmour, D., Knaut, H., Maischein, H.M., and Nüsslein-Volhard, C. (2004) Towing of sensory axons by their migrating target cells in vivo. Nature Neuroscience. 7(5):491-492
Dekens, M.P., Pelegri, F.J., Maischein, H.M., and Nüsslein-Volhard, C. (2003) The maternal-effect gene futile cycle is essential for pronuclear congression and mitotic spindle assembly in the zebrafish zygote. Development (Cambridge, England). 130(17):3907-3916
Maderspacher, F. and Nüsslein-Volhard, C. (2003) Formation of the adult pigment pattern in zebrafish requires leopard and obelix dependent cell interactions. Development (Cambridge, England). 130(15):3447-3457
Knaut, H., Werz, C., Geisler, R., The Tübingen 2000 Screen Consortium, Nüsslein-Volhard, C. (2003) A zebrafish homologue of the chemokine receptor Cxcr4 is a germ-cell guidance receptor. Nature. 421(6920):279-282
Klisa, C., Bayley, P., Lyons, D.A., Nüsslein-Volhard, C., Clarke, J.D.W., Brand, M., and Wilson, S.W. (2002) Identification and characterization of novel zebrafish brain development mutants by large-scale mutagenesis screening. Developmental Biology. 247(2):447
Gilmour, D.T., Maischein, H.M., Nüsslein-Volhard, C. (2002) Migration and function of a glial subtype in the vertebrate peripheral nervous system. Neuron. 34(4):577-588
Holley, S.A., Jülich, D., Rauch, G.J., Geisler, R., and Nüsslein-Volhard, C. (2002) her1 and the notch pathway function within the oscillator mechanism that regulates zebrafish somitogenesis. Development (Cambridge, England). 129(5):1175-1183
Knaut, H., Steinbeisser, H., Schwarz, H., and Nüsslein-Volhard, C. (2002) An evolutionary conserved region in the vasa 3'UTR targets RNA translation to the germ cells in the zebrafish. Current biology : CB. 12(6):454-466
Nüsslein-Volhard, C. and Dahm, R. (2002) Zebrafish: a practical approach. New York: Oxford University Press. :303p
Davidson, A.J., Dooley, K., Schmidt, B., Paffett-Lugassy, N., White, N., Walderich, B., Odenthal, J., Maischein, H.M., Schulte-Merker, S., Nüsslein-Volhard, C., Thisse, C., Thisse, B., and Zon, L.I. (2001) Functional genomics and mutagenesis screening in the zebrafish identifies genes required for hematopoietic stem cell development. Blood.. 98(11):1888
Neumann, C.J. and Nüsslein-Volhard, C. (2000) Patterning of the zebrafish retina by a wave of sonic hedgehog activity. Science (New York, N.Y.). 289(5487):2137-2139
Piotrowski, T. and Nüsslein-Volhard, C. (2000) The endoderm plays an important role in patterning the segmented pharyngeal region in zebrafish (Danio rerio). Developmental Biology. 225(2):339-356
Holley, S.A., Geisler, R., and Nüsslein-Volhard, C. (2000) Control of her1 expression during zebrafish somitogenesis by a Delta-dependent oscillator and an independent wave-front activity. Genes and Development. 14(13):1678-1690
Knaut, H., Pelegri, F., Bohmann, K., Schwarz, H., and Nüsslein-Volhard, C. (2000) Zebrafish vasa RNA but not its protein is a component of the germ plasm and segregates asymmetrically before germline specification. The Journal of cell biology. 149(4):875-888
Odenthal, J., van Eeden, F.J., Haffter, P., Ingham, P.W., and Nüsslein-Volhard, C. (2000) Two distinct cell populations in the floor plate of the zebrafish are induced by different pathways. Developmental Biology. 219(2):350-363
Holley, S.A. and Nüsslein-Volhard, C. (2000) Somitogenesis in Zebrafish. Current topics in developmental biology. 47:248-277
Nüsslein-Volhard, C. and Krätzschmar, J. (2000) Of fish, fly, worm, and man: lessons from developmental biology for human gene function and disease. Berlin, New York: Springer. :239 p
Pelegri, F., Knaut, H., Maischein, H.M., Schulte-Merker, S., and Nüsslein-Volhard, C. (1999) A mutation in the zebrafish maternal-effect gene nebel affects furrow formation and vasa RNA localization. Current biology : CB. 9(24):1431-1440
Neumann, C.J., Grandel, H., Gaffield, W., Schulte-Merker, S., Nüsslein-Volhard, C. (1999) Transient establishment of anteroposterior polarity in the zebrafish pectoral fin bud in the absence of sonic hedgehog activity. Development (Cambridge, England). 126(21):4817-4826
Geisler, R., Rauch, G.J., Baier, H., van Bebber, F., Brobeta, L., Dekens, M.P., Finger, K., Fricke, C., Gates, M.A., Geiger, H., Geiger-Rudolph, S., Gilmour, D., Glaser, S., Gnugge, L., Habeck, H., Hingst, K., Holley, S., Keenan, J., Kirn, A., Knaut, H., Lashkari, D., Maderspacher, F., Martyn, U., Neuhauss, S., Neumann, C., Nicolson, T., Pelegri, F., Ray, R., Rick, J.M., Roehl, H., Roeser, T., Schauerte, H.E., Schier, A.F., Schönberger, U., Schönthaler, H.-B., Schulte-Merker, S., Seydler, C., Talbot, W.S., Weiler, C., Nüsslein-Volhard, C., and Haffter, P. (1999) A radiation hybrid map of the zebrafish genome. Nature Genetics. 23(1):86-89
Warga, R.M. and Nüsslein-Volhard, C. (1999) Origin and development of the zebrafish endoderm. Development (Cambridge, England). 126:827-838
Ribera, A.B. and Nüsslein-Volhard, C. (1998) Zebrafish touch-insensitive mutants reveal an essential role for the developmental regulation of sodium current. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18:9181-9191
Warga, R.M. and Nüsslein-Volhard, C. (1998) Spadetail-dependent cell compaction of the dorsal zebrafish blastula. Developmental Biology. 203:116-121
Odenthal, J. and Nüsslein-Volhard, C. (1998) fork head domain genes in zebrafish. Development genes and evolution. 208:245-258
van Eeden, F.J.M., Holley, S.A., Haffter, P., and Nüsslein-Volhard, C. (1998) Zebrafish segmentation and pair-rule patterning. Developmental genetics. 23:65-76
Nicolson, T., Rüsch, A., Friedrich, R.W., Granato, M., Ruppersberg, J.P., and Nüsslein-Volhard, C. (1998) Genetic analysis of vertebrate sensory hair cell mechanosensation: the zebrafish circler mutants. Neuron. 20:271-283
Chen, J.-N., van Eeden, F.J.M., Warren, K.S., Chin, A., Nüsslein-Volhard, C., Haffter, P., and Fishman, M.C. (1997) Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development (Cambridge, England). 124(21):4373-4382
Heisenberg, C.P. and Nüsslein-Volhard, C. (1997) The function of silberblick in the positioning of the eye anlage in the zebrafish embryo. Developmental Biology. 184(1):85-94
Baier, H., Klostermann, S., Trowe, T., Karlstrom, R.O., Nüsslein-Volhard, C., and Bonhoeffer, F. (1996) Genetic dissection of the retinotectal projection. Development (Cambridge, England). 123:415-425
Brand, M., Heisenberg, C.P., Jiang, Y.J., Beuchle, D., Lun, K., Furutani-Seiki, M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., van Eeden, F.J., and Nüsslein-Volhard, C. (1996) Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain. Development (Cambridge, England). 123:179-190
Brand, M., Heisenberg, C.P., Warga, R.M., Pelegri, F., Karlstrom, R.O., Beuchle, D., Picker, A., Jiang, Y.J., Furutani-Seiki, M., van Eeden, F.J., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Mutations affecting development of the midline and general body shape during zebrafish embryogenesis. Development (Cambridge, England). 123:129-142
Chen, J.N., Haffter, P., Odenthal, J., Vogelsang, E., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., and Nüsslein-Volhard, C. (1996) Mutations affecting the cardiovascular system and other internal organs in zebrafish. Development (Cambridge, England). 123:293-302
Furutani-Seiki, M., Jiang, Y.J., Brand, M., Heisenberg, C.P., Houart, C., Beuchle, D., van Eeden, F.J.M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Neural degeneration mutants in the zebrafish, Danio rerio. Development (Cambridge, England). 123:229-239
Granato, M., van Eeden, F.J., Schach, U., Trowe, T., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva. Development (Cambridge, England). 123:399-413
Haffter, P., Granato, M., Brand, M., Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., van Eeden, F.J., Jiang, Y.J., Heisenberg, C.P., Kelsh, R.N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C., and Nüsslein-Volhard, C. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development (Cambridge, England). 123:1-36
Hammerschmidt, M., Pelegri, F., Mullins, M.C., Kane, D.A., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Heisenberg, C.P., Jiang, Y.J., Kelsh, R.N., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C. (1996) Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio. Development (Cambridge, England). 123:143-151
Hammerschmidt, M., Pelegri, F., Mullins, M.C., Kane, D.A., van Eeden, F.J., Granato, M., Brand, M., Furutani-Seiki, M., Haffter, P., Heisenberg, C.P., Jiang, Y.J., Kelsh, R.N., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C. (1996) dino and mercedes, two genes regulating dorsal development in the zebrafish embryo. Development (Cambridge, England). 123:95-102
Heisenberg, C.P., Brand, M., Jiang, Y.J., Warga, R.M., Beuchle, D., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Genes involved in forebrain development in the zebrafish, Danio rerio. Development (Cambridge, England). 123:191-203
Jiang, Y.J., Brand, M., Heisenberg, C.P., Beuchle, D., Furutani-Seiki, M., Kelsh, R.N., Warga, R.M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Mullins, M.C., Odenthal, J., van Eeden, F.J., and Nüsslein-Volhard, C. (1996) Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio. Development (Cambridge, England). 123:205-216
Kane, D.A., Hammerschmidt, M., Mullins, M.C., Maischein, H.M., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Heisenberg, C.P., Jiang, Y.J., Kelsh, R.N., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C. (1996) The zebrafish epiboly mutants. Development (Cambridge, England). 123:47-55
Kane, D.A., Maischein, H.M., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Hammerschmidt, M., Heisenberg-, C.P., Jiang, Y.J., Kelsh, R.N., Mullins, M.C., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C. (1996) The zebrafish early arrest mutants. Development (Cambridge, England). 123:57-66
Karlstrom, R.O., Trowe, T., Klostermann, S., Baier, H., Brand, M., Crawford, A.D., Grunewald, B., Haffter, P., Hoffman, H., Meyer, S.U., Muller, B.K., Richter, S., van Eeden, F.J., Nüsslein-Volhard, C., and Bonhoeffer, F. (1996) Zebrafish mutations affecting retinotectal axon pathfinding. Development (Cambridge, England). 123:427-438
Kelsh, R.N., Brand, M., Jiang, Y.J., Heisenberg, C.P., Lin, S., Haffter, P., Odenthal, J., Mullins, M.C., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Kane, D.A., Warga, R.M., Beuchle, D., Vogelsang, L., and Nüsslein-Volhard, C. (1996) Zebrafish pigmentation mutations and the processes of neural crest development. Development (Cambridge, England). 123:369-389
Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Heisenberg, C.P., Jiang, Y.J., Kelsh, R.N., and Nüsslein-Volhard, C. (1996) Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes. Development (Cambridge, England). 123:81-93
Odenthal, J., Haffter, P., Vogelsang, E., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Warga, R.M., Allende, M.L., Weinberg, E.S., and Nüsslein-Volhard, C. (1996) Mutations affecting the formation of the notochord in the zebrafish, Danio rerio. Development (Cambridge, England). 123:103-115
Odenthal, J., Rossnagel, K., Haffter, P., Kelsh, R.N., Vogelsang, E., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Mullins, M.C., and Nüsslein-Volhard, C. (1996) Mutations affecting xanthophore pigmentation in the zebrafish, Danio rerio. Development (Cambridge, England). 123:391-398
Piotrowski, T., Schilling, T.F., Brand, M., Jiang, Y.J., Heisenberg, C.P., Beuchle, D., Grandel, H., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C. (1996) Jaw and branchial arch mutants in zebrafish. II. Anterior arches and cartilage differentiation. Development (Cambridge, England). 123:345-356
Ransom, D.G., Haffter, P., Odenthal, J., Brownlie, A., Vogelsang, E., Kelsh, R.N., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Mullins, M.C., and Nüsslein-Volhard, C. (1996) Characterization of zebrafish mutants with defects in embryonic hematopoiesis. Development (Cambridge, England). 123:311-319
Schilling, T.F., Piotrowski, T., Grandel, H., Brand, M., Heisenberg, C.P., Jiang, Y.J., Beuchle, D., Hammerschmidt, M., Kane, D.A., Mullins, M.C., van Eeden, F.J., Kelsh, R.N., Furutani-Seiki, M., Granato, M., Haffter, P., Odenthal, J., Warga, R.M., Trowe, T., and Nüsslein-Volhard, C. (1996) Jaw and branchial arch mutants in zebrafish. I. Branchial arches. Development (Cambridge, England). 123:329-344
Trowe, T., Klostermann, S., Baier, H., Granato, M., Crawford, A.D., Grunewald, B., Hoffman, H., Karlstrom, R.O., Meyer, S.U., Muller, B., Richter, S., Nüsslein-Volhard, C., and Bonhoeffer, F. (1996) Mutations disrupting the ordering and topographic mapping of axons in the retinotectal projection of the zebrafish, Danio rerio. Development (Cambridge, England). 123:439-450
van Eeden, F.J., Granato, M., Schach, U., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C. (1996) Genetic analysis of fin formation in the zebrafish, Danio rerio. Development (Cambridge, England). 123:255-262
van Eeden, F.J., Granato, M., Schach, U., Brand, M., Furutani-Seiki-, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., Warga, R.M., Allende, M.L., Weinberg, E.S., and Nüsslein-Volhard, C. (1996) Mutations affecting somite formation and patterning in the zebrafish, Danio rerio. Development (Cambridge, England). 123:153-164
Whitfield, T.T., Granato, M., van Eeden, F.J., Schach, U., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Mutations affecting development of the zebrafish inner ear and lateral line. Development (Cambridge, England). 123:241-254
Haffter, P., Odenthal, J., Mullins, M.C., Lin, S., Farrell, M.J., Vogelsang, E., Haas, F., Brand, M., van Eeden, F.J.M., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Hopkins, N., and Nüsslein-Volhard, C. (1996) Mutations affecting pigmentation and shape of the adult zebrafish. Development genes and evolution. 206(4):260-276
Granato, M. and Nüsslein-Volhard, C. (1996) Fishing for genes controlling development. Current opinion in genetics & development. 6(4):461-468
Haffter, P. and Nüsslein-Volhard, C. (1996) Large scale genetics in a small vertebrate, the zebrafish. The International journal of developmental biology. 40:221-227
Mullins, M.C., Hammerschmidt, M., Haffter, P., and Nüsslein-Volhard, C. (1994) Large-scale mutagenesis in the zebrafish: in search of genes controlling development in a vertebrate. Current biology : CB. 4:189-202
Nüsslein-Volhard, C. (1994) Of flies and fishes. Science (New York, N.Y.). 266:572-574
Schulte-Merker, S., Hammerschmidt, M., Beuchle, D., Cho, K.W., De Robertis, E.M., and Nüsslein-Volhard, C. (1994) Expression of zebrafish goosecoid and no tail gene products in wild-type and mutant no tail embryos. Development (Cambridge, England). 120:843-852
Schulte-Merker, S., van Eeden, F.J.M., Halpern, M.E., Kimmel, C.B., and Nüsslein-Volhard, C. (1994) no tail (ntl) is the zebrafish homologue of the mouse T (Brachyury) gene. Development (Cambridge, England). 120:1009-1015
Hammerschmidt, M. and Nüsslein-Volhard, C. (1993) The expression of a zebrafish gene homologous to Drosophila snail suggests a conserved function in invertebrate and vertebrate gastrulation. Development (Cambridge, England). 119:1107-1118
Mullins, M.C. and Nüsslein-Volhard, C. (1993) Mutational approaches to studying embryonic pattern formation in the zebrafish. Current opinion in genetics & development. 3:648-654
Schulte-Merker, S., Ho, R.K., Herrmann, B.G., and Nüsslein-Volhard, C. (1992) The protein product of the zebrafish homologue of the mouse T gene is expressed in nuclei of the germ ring and the notochord of the early embryo. Development (Cambridge, England). 116:1021-1032
Culp, P., Nüsslein-Volhard, C., and Hopkins, N. (1991) High-frequency germ-line transmission of plasmid DNA sequences injected into fertilized zebrafish eggs. Proc. Natl. Acad. Sci. USA. 88:7953-7957