GENOMIC FEATURES ORIGINATING FROM THIS LABNo data available
We investigate the molecular evolution, early development and regulation of the immune system, particularly "rearranging" genes (immunoglobulins, T-cell receptors and variable lymphocyte receptors) and those involved in lymphopoeisis. We also study the evolution of developmental regulation (hox and dlx genes) in chordates. Our laboratory is actively involved in incorporating large-fragment molecular cloning methods for novel developmental genetic studies and for "comparative genomics." We are developing improved transgenic methods for BACs in order to generate zebrafish models of human disease.