ZFIN ID: ZDB-LAB-170208-8
Development and functional regulation of BBB
PI/Director: Zhang, Jingjing
Contact Person: Zhang, Jingjing
Email: jj.zhang@gdmu.edu.cn; gdmccrc@163.com
URL: http://www.gdmch.com/zebrafish
Address: Clinical Research Center, Affiliate Hospital of Guangdong Medical University Nr. 57 Renmin Dadao Nan, Zhanjiang 524001, China
Country: China
Phone: +86-759-2387140
Line Designation: gyf

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The research interests of our lab are the development and functional modulations of tissue barriers including blood-brain barrier (BBB) and epithelial barriers. Using in vitro systems, zebrafish and mice models, our group focuses on (1) the developmental roles of Claudin family members on the barrier formation; (2) using synthesized peptides to selectively open tight junctions for the drug delivery; (3) the interactions between endothelial cells and pericytes and/or astrocytes during BBB formation; (4) protective and repair mechanisms under pathological and ischemic conditions.


Zhong, X., Zhang, G., Huang, J., Chen, L., Shi, Y., Wang, D., Zheng, Q., Su, H., Li, X., Wang, C., Zhang, J., Guo, L. (2024) Effects of Intestinal Microbiota on the Biological Transformation of Arsenic in Zebrafish: Contribution and Mechanism. Environmental science & technology. 58(5):2247-2259
Liu, Q., Song, T., Chen, B., Zhang, J., Li, W. (2023) Ferroptosis of brain microvascular endothelial cells contributes to hypoxia-induced blood-brain barrier injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37:e22874e22874
Xie, H., Kang, Y., Liu, J., Huang, M., Dai, Z., Shi, J., Wang, S., Li, L., Li, Y., Zheng, P., Sun, Y., Han, Q., Zhang, J., Zhu, Z., Xu, L., Yelick, P.C., Cao, M., Zhao, C. (2023) Ependymal polarity defects coupled with disorganized ciliary beating drive abnormal cerebrospinal fluid flow and spine curvature in zebrafish. PLoS Biology. 21:e3002008e3002008
Li, Y., Wang, C., Zhang, L., Chen, B., Mo, Y., Zhang, J. (2022) Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier. Fluids and barriers of the CNS. 19:40
Fu, S., Tan, R., Feng, Y., Yu, P., Mo, Y., Xiao, W., Wang, S., Zhang, J. (2022) N-methyl-N-nitrosourea induces zebrafish anomalous angiogenesis through Wnt/β-catenin pathway. Ecotoxicology and environmental safety. 239:113674
Liu, X., Lu, X., Hong, J., Zhang, J., Lin, J., Jiang, M., Liu, Q., Choi, K., Zhang, J. (2022) Effects of long-term exposure to TDCPP in zebrafish (Danio rerio) - Alternations of hormone balance and gene transcriptions along hypothalamus-pituitary axes. Animal models and experimental medicine. 5(3):239-247
Li, W., Li, X., Ma, X., Xiao, W., Zhang, J. (2022) Mapping the m1A, m5C, m6A and m7G methylation atlas in zebrafish brain under hypoxic conditions by MeRIP-seq. BMC Genomics. 23:105
Huang, E., Huang, H., Wu, L., Li, B., He, Z., Zhang, J. (2022) Establishment of a Zebrafish Xenograft Model for in Vivo Investigation of Nasopharyngeal Carcinoma. Cell transplantation. 31:9636897221116085
Chen, L., Wang, J., Cai, X., Chen, S., Zhang, J., Li, B., Chen, W., Guo, X., Luo, H., Chen, J. (2021) Cyclometalated Ru(II)-isoquinoline complexes overcome cisplatin resistance of A549/DDP cells by downregulation of Nrf2 via Akt/GSK-3β/Fyn pathway. Bioorganic chemistry. 119:105516
Chen, J., Deng, Y., Wang, J., Chen, S., Peng, F., He, X., Liu, M., Luo, H., Zhang, J., Chen, L. (2021) Cyclometalated Ru(II) β-carboline complexes induce cell cycle arrest and apoptosis in human HeLa cervical cancer cells via suppressing ERK and Akt signaling. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 26(7):793-808
Yang, Z., Wu, S., Fontana, F., Li, Y., Xiao, W., Gao, Z., Stephan, A., Affolter, M., Belting, H.G., Abdelilah-Seyfried, S., Zhang, J. (2020) The tight junctions protein Claudin-5 limits endothelial cell motility. Journal of Cell Science. 134(1):
Yang, Z., Lin, P., Chen, B., Zhang, X., Xiao, W., Wu, S., Huang, C., Feng, D., Zhang, W., Zhang, J. (2020) Autophagy alleviates hypoxia-induced blood-brain barrier injury via regulation of CLDN5 (claudin 5). Autophagy. 17(10):3048-3067
Feng, Y., Yu, P., Li, J., Cao, Y., Zhang, J. (2020) Phosphatidylinositol 4-kinase β is required for the ciliogenesis of zebrafish otic vesicle. Journal of genetics and genomics = Yi chuan xue bao. 47(10):627-636
Gan, D., Wu, S., Chen, B., Zhang, J. (2019) Application of the Zebrafish Traumatic Brain Injury Model in Assessing Cerebral Inflammation. Zebrafish. 17(2):73-82
Huang, Y., Lu, Y., He, Y., Feng, Z., Zhan, Y., Huang, X., Liu, Q., Zhang, J., Li, H., Huang, H., Ma, M., Luo, L., Li, L. (2019) Ikzf1 regulates embryonic T lymphopoiesis via Ccr9 & Irf4 in zebrafish. The Journal of biological chemistry. 294(44):16152-16163
Zhan, Y., Huang, Y., Chen, J., Cao, Z., He, J., Zhang, J., Huang, H., Ruan, H., Luo, L., Li, L. (2018) The caudal dorsal artery generates hematopoietic stem and progenitor cells via the endothelial-to-hematopoietic transition in zebrafish. Journal of genetics and genomics = Yi chuan xue bao.
Zheng, Y., Li, J., Wu, J., Yu, Y., Yao, W., Zhou, M., Tian, J., Zhang, J., Cui, L., Zeng, X., Liu, Y. (2017) Tetrahydroxystilbene glucoside isolated from Polygonum multiflorum Thunb. demonstrates osteoblast differentiation promoting activity.. Experimental and Therapeutic Medicine. 14:2845-2852
Zhang, J., Qi, J., Wu, S., Peng, L., Shi, Y., Yang, J., Yin, Z., Gao, Y., Wang, C., Gong, J., Zhang, H., Zhang, J., Liu, D. (2017) Fatty Acid Binding Protein 11a Is Required for Brain Vessel Integrity in Zebrafish. Frontiers in Physiology. 8:214
Zhang, J.J., Wang, X., Liu, D. (2017) [Natriuretic peptide precursor C coding gene contributes to zebrafish angiogenesis]. Sheng li xue bao : [Acta physiologica Sinica]. 69:11-16
Hou, Y., Sheng, Z., Mao, X., Li, C., Chen, J., Zhang, J., Huang, H., Ruan, H., Luo, L., Li, L. (2016) Systemic inoculation of Escherichia coli causes emergency myelopoiesis in zebrafish larval caudal hematopoietic tissue. Scientific Reports. 6:36853
Luo, S., Yang, Y., Chen, J., Zhong, Z., Huang, H., Zhang, J., Cui, L. (2015) Tanshinol stimulates bone formation and attenuates dexamethasone-induced inhibition of osteogenesis in larval zebrafish. Journal of orthopaedic translation. 4:35-45