ZFIN Lab: Laboratory of Optical Neuroimaging

ZFIN ID: ZDB-LAB-170208-11

ZFIN ID: ZDB-LAB-170208-11

Laboratory of Optical Neuroimaging

PI/Director:	Wang, Kai
Contact Person:	Wang, Kai
Email:	wangkai@ion.ac.cn
URL:
Address:	Institute of Neuroscience Chinese Academy of Sciences 320 Yueyang Road Shanghai, 200031 China
Country:	China
Phone:	86-21-54921855
Fax:
Line Designation:	None assigned

GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available

STATEMENT OF RESEARCH INTERESTS

We are interested in developing novel optical imaging methods for structural and functional brain imaging. Zebrafish serves as an important model in neuroscience to study neural network dynamics at single neuron level and across the whole brain.

LAB MEMBERS

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Bai, L., Zhang, Z., Ye, L., Cong, L., Zhao, Y., Zhang, T., Shi, Z., Wang, K. (2022) Volumetric Imaging of Neural Activity by Light Field Microscopy. Neuroscience Bulletin. 38(12):1559-1568

Zhang, Z., Cong, L., Bai, L., Wang, K. (2021) Light-field Microscopy for Fast Volumetric Brain Imaging. Journal of Neuroscience Methods. 352:109083

Zhang, Z., Bai, L., Cong, L., Yu, P., Zhang, T., Shi, W., Li, F., Du, J., Wang, K. (2020) Imaging volumetric dynamics at high speed in mouse and zebrafish brain with confocal light field microscopy. Nature Biotechnology. 39(1):74-83

Liu, T.L., Upadhyayula, S., Milkie, D.E., Singh, V., Wang, K., Swinburne, I.A., Mosaliganti, K.R., Collins, Z.M., Hiscock, T.W., Shea, J., Kohrman, A.Q., Medwig, T.N., Dambournet, D., Forster, R., Cunniff, B., Ruan, Y., Yashiro, H., Scholpp, S., Meyerowitz, E.M., Hockemeyer, D., Drubin, D.G., Martin, B.L., Matus, D.Q., Koyama, M., Megason, S.G., Kirchhausen, T., Betzig, E. (2018) Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms. Science (New York, N.Y.). 360(6386):

Cong, L., Wang, Z., Chai, Y., Hang, W., Shang, C., Yang, W., Bai, L., Du, J., Wang, K., Wen, Q. (2017) Rapid whole brain imaging of neural activity in freely behaving larval zebrafish (Danio rerio).. eLIFE. 6

Xia, Z., Wei, J., Li, Y., Wang, J., Li, W., Wang, K., Hong, X., Zhao, L., Chen, C., Min, J., Wang, F. (2017) Zebrafish slc30a10 deficiency revealed a novel compensatory mechanism of Atp2c1 in maintaining manganese homeostasis. PLoS Genetics. 13:e1006892

Chen, D., Tang, J., Wan, Q., Zhang, J., Wang, K., Shen, Y., Yu, Y. (2017) E-Prostanoid 3 Receptor Mediates Sprouting Angiogenesis Through Suppression of the Protein Kinase A/β-Catenin/Notch Pathway. Arteriosclerosis, Thrombosis, and Vascular Biology. 37(5):856-866

Zhang, C., Li, C., Chen, S., Li, Z., Jia, X., Wang, K., Bao, J., Liang, Y., Wang, X., Chen, M., Li, P., Su, H., Wan, J.B., Lee, S.M., Liu, K., He, C. (2017) Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways. Redox Biology. 11:1-11

Zhang, C., Li, C., Chen, S., Li, Z., Ma, L., Jia, X., Wang, K., Bao, J., Liang, Y., Chen, M., Li, P., Su, H., Lee, S.M., Liu, K., Wan, J.B., He, C. (2017) Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways. Scientific Reports. 7:41082