ZFIN ID: ZDB-LAB-140410-1
Yiyue ZHANG Lab
PI/Director: Zhang, Yiyue
Contact Person: Zhang, Yiyue
Email: mczhangyy@scut.edu.cn
URL:
Address: Yiyue ZHANG Lab Division of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology Guangzhou, 510006, P.R. China
Country: China
Phone:
Fax:
Line Designation: szy


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 11 genomic features


STATEMENT OF RESEARCH INTERESTS
We are interested in developmental biology of hematopoiesis using zebrafish as a model organism.
Our group currently focus on:
(1) Genetic control and molecular regulation of myeloid cell development.
(2) Thrombocyte formation during embryonic development.
(3) The regulatory mechanism of HSC migration in early development.


LAB MEMBERS
Di, Qianqian Graduate Student Lian, Junwei Graduate Student Lin, Qing Graduate Student
Liu, Yongxiang Graduate Student Meng, Ping Graduate Student Wu, Mei Graduate Student
Zhang, Yangping Graduate Student Zhou, Riyang Graduate Student


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS x
Chi, Y., Huang, Z., Chen, Q., Xiong, X., Chen, K., Xu, J., Zhang, Y., Zhang, W. (2018) Loss of runx1 function results in B cell immunodeficiency but not T cell in adult zebrafish.. Open Biology. 8(7):
Lian, J., Chen, J., Wang, K., Zhao, L., Meng, P., Yang, L., Wei, J., Ma, N., Xu, J., Zhang, W., Zhang, Y. (2018) Alas1 is essential for neutrophil maturation in zebrafish. Haematologica. 103(11):1785-1795
Zhang, Z., Liu, W., Zhao, L., Huang, Z., Chen, X., Ma, N., Xu, J., Zhang, W., Zhang, Y. (2017) Rb1 promotes T cell maturation from premature apoptosis by inhibiting E2F1. Development (Cambridge, England). 145(1)
Tu, H., Peng, T., Liu, J., Chen, X., Fan, C., Huang, Z., Zhang, Y., Zou, F., Meng, X. (2017) Role of neurexin2a in lead-induced locomotor defect in developing zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 194:167-175
Di, Q., Lin, Q., Huang, Z., Chi, Y., Chen, X., Zhang, W., Zhang, Y. (2017) Zebrafish nephrosin helps host defence against Escherichia coli infection.. Open Biology. 7(8)
Tu, H., Fan, C., Chen, X., Liu, J., Wang, B., Huang, Z., Zhang, Y., Meng, X., Zou, F. (2017) Effects of cadmium, manganese and lead on locomotor activity and neurexin2a expression in zebrafish. Environmental toxicology and chemistry. 36(8):2147-2154
Lin, Q., Zhang, Y., Zhou, R., Zheng, Y., Zhao, L., Huang, M., Zhang, X., Leung, A.Y., Zhang, W., Zhang, Y. (2017) Establishment of a congenital amegakaryocytic thrombocytopenia model and a thrombocyte-specific reporter line in zebrafish. Leukemia. 31(5):1206-1216
Liu, W., Wu, M., Huang, Z., Lian, J., Chen, J., Wang, T., Leung, A.Y., Liao, Y., Zhang, Z., Liu, Q., Yen, K., Lin, S., Zon, L.I., Wen, Z., Zhang, Y., Zhang, W. (2017) c-myb hyperactivity leads to myeloid and lymphoid malignancies in zebrafish. Leukemia. 31(1):222-233
Wang, L., Jiang, W., Lin, Q., Zhang, Y., Zhao, C. (2016) DNA methylation regulates gabrb2 mRNA expression: Developmental variations and disruptions in L-Methionine-induced zebrafish with schizophrenia-like symptoms. Genes, brain, and behavior. 15(8):702-710
Dai, Y., Zhu, L., Huang, Z., Zhou, M., Jin, W., Liu, W., Xu, M., Yu, T., Zhang, Y., Wen, Z., Liao, W., Zhang, W. (2016) Cebpα is essential for the embryonic myeloid progenitor and neutrophil maintenance in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 43(10):593-600
Meng, P., Liu, Y., Chen, X., Zhang, W., Zhang, Y. (2016) Zebrafish Cdh5 negatively regulates mobilization of aorta-gonad-mesonephros-derived hematopoietic stem cells. Journal of genetics and genomics = Yi chuan xue bao. 43(10):613-616
Jin, H., Huang, Z., Chi, Y., Wu, M., Zhou, R., Zhao, L., Xu, J., Zhen, F., Lan, Y., Li, L., Zhang, W., Wen, Z., Zhang, Y. (2016) cMyb acts in parallel and cooperatively with Cebp1 to regulate neutrophil maturation in zebrafish. Blood. 128(3):415-26
Guo, P., Huang, Z., Tao, T., Chen, X., Zhang, W., Zhang, Y., Lin, C. (2015) Zebrafish as a model for studying the developmental neurotoxicity of propofol. Journal of applied toxicology : JAT. 35(12):1511-9
Dai, W., Wang, K., Zheng, X., Chen, X., Zhang, W., Zhang, Y., Hou, J., Liu, L. (2015) High fat plus high cholesterol diet lead to hepatic steatosis in zebrafish larvae: a novel model for screening anti-hepatic steatosis drugs. Nutrition & metabolism. 12:42
Hao, K., Li, Y., Feng, J., Zhang, W., Zhang, Y., Ma, N., Zeng, Q., Pang, H., Wang, C., Xiao, L., He, X. (2015) Ozone promotes regeneration by regulating the inflammatory response in zebrafish. International Immunopharmacology. 28(1):369-75
Wang, K., Fang, X., Ma, N., Lin, Q., Huang, Z., Liu, W., Xu, M., Chen, X., Zhang, W., Zhang, Y. (2015) Myeloperoxidase-deficient Zebrafish show an Augmented Inflammatory Response to Challenge with Candida albicans. Fish & shellfish immunology. 44(1):109-16
He, B.L., Shi, X., Man, C.H., Ma, A.C., Ekker, S.C., Chow, H.C., So, C.W., Choi, W.W., Zhang, W., Zhang, Y., and Leung, A.Y. (2014) Functions of FMS-like tyrosine kinase 3 (flt3) in zebrafish hematopoiesis and its relevance to human acute myeloid leukemia. Blood. 123(16):2518-29
Sun, J., Liu, W., Li, L., Chen, J., Wu, M., Zhang, Y., Leung, A.Y., Zhang, W., Wen, Z., and Liao, W. (2013) Suppression of Pu.1 Function results in expanded myelopoiesis in zebrafish. Leukemia. 27(9):1913-7
Wang, K., Huang, Z., Zhao, L., Liu, W., Chen, X., Meng, P., Lin, Q., Chi, Y., Xu, M., Ma, N., Zhang, Y., and Zhang, W. (2012) Large-scale forward genetic screening analysis of development of hematopoiesis in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 39(9):473-480
Zhang, Y., Jin, H., Li, L., Qin, F.X., and Wen, Z. (2011) cMyb regulates hematopoietic stem/progenitor cell mobilization during zebrafish hematopoiesis. Blood. 118(15):4093-101