ZFIN ID: ZDB-LAB-140127-1
Dallman Lab
PI/Director: Dallman, Maggie
Contact Person: Dallman, Maggie
Email: m.dallman@imperial.ac.uk
URL: http://www3.imperial.ac.uk/dallmanlab
Address: Department of Life Sciences Sir Alexander Fleming Building Imperial College London SW7 2AZ, London UK
Country: United Kingdom
Line Designation: icl

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Our research includes studies in immunology and inflammation, and its relationship to conditions such as atherosclerosis, obesity and COPD. An ability to generate immune responses to invading pathogens is vital to our well being and survival yet over-vigorous or inappropriate responses can lead to debilitating or life threatening conditions such as autoimmunity (e.g. diabetes, rheumatoid arthritis) and allergy. Further, as our understanding of disease develops we find that dysregulated inflammatory responses are associated with conditions as diverse as COPD and obesity. An understanding of and an ability to control inappropriate immunity and inflammation lie therefore on the path to successful treatment of these varied diseases.

Progatzky, Fränze Post-Doc Ramel, Marie-Christine Post-Doc Andrews, Natalie Graduate Student
Charlwood, Kathryn Graduate Student McBrien, Marie Graduate Student Bugeon, Laurence Research Staff
Lamb, Jonathan Research Staff

Høgset, H., Horgan, C.C., Armstrong, J.P.K., Bergholt, M.S., Torraca, V., Chen, Q., Keane, T.J., Bugeon, L., Dallman, M.J., Mostowy, S., Stevens, M.M. (2020) In vivo biomolecular imaging of zebrafish embryos using confocal Raman spectroscopy. Nature communications. 11:6172
Wenz, R., Conibear, E., Bugeon, L., Dallman, M. (2020) Fast, easy and early (larval) identification of transparent mutant zebrafish using standard fluorescence microscopy. F1000Research. 9:963
Bottiglione, F., Dee, C.T., Lea, R., Zeef, L.A.H., Badrock, A.P., Wane, M., Bugeon, L., Dallman, M.J., Allen, J.E., Hurlstone, A.F.L. (2020) Zebrafish IL-4-like Cytokines and IL-10 Suppress Inflammation but Only IL-10 Is Essential for Gill Homeostasis. Journal of immunology (Baltimore, Md. : 1950). 205(4):994-1008
Moroz-Omori, E.V., Satyapertiwi, D., Ramel, M.C., Høgset, H., Sunyovszki, I.K., Liu, Z., Wojciechowski, J.P., Zhang, Y., Grigsby, C.L., Brito, L., Bugeon, L., Dallman, M.J., Stevens, M.M. (2020) Photoswitchable gRNAs for Spatiotemporally Controlled CRISPR-Cas-Based Genomic Regulation. ACS central science. 6:695-703
Progatzky, F., Jha, A., Wane, M., Thwaites, R.S., Makris, S., Shattock, R.J., Johansson, C., Openshaw, P.J., Bugeon, L., Hansel, T.T., Dallman, M.J. (2019) Induction of innate cytokine responses by respiratory mucosal challenge with R848 in zebrafish, mice and humans. The Journal of allergy and clinical immunology. 144(1):342-345.e7
Price, R.L., Bugeon, L., Mostowy, S., Makendi, C., Wren, B.W., Williams, H.D., Willcocks, S.J. (2019) In vitro and in vivo properties of the bovine antimicrobial peptide, Bactenecin 5. PLoS One. 14:e0210508
Vervoort, S.J., de Jong, O.G., Roukens, M.G., Frederiks, C.L., Vermeulen, J.F., Lourenço, A.R., Bella, L., Vidakovic, A.T., Sandoval, J.L., Moelans, C., van Amersfoort, M., Dallman, M.J., Bruna, A., Caldas, C., Nieuwenhuis, E., van der Wall, E., Derksen, P., van Diest, P., Verhaar, M.C., Lam, E.W., Mokry, M., Coffer, P.J. (2018) Global transcriptional analysis identifies a novel role for SOX4 in tumor-induced angiogenesis. eLIFE. 7:
Li, S.S., Xu, L.Z., Zhou, W., Yao, S., Wang, C.L., Xia, J.L., Wang, H.F., Kamran, M., Xue, X.Y., Dong, L., Wang, J., Ding, X.D., Bella, L., Bugeon, L., Xu, J., Zheng, F.M., Dallman, M.J., Lam, E.W., Liu, Q. (2017) p62/SQSTM1 interacts with vimentin to enhance breast cancer metastasis. Carcinogenesis. 38(11):1092-1103
Watson, T., Andrews, N., Davis, S., Bugeon, L., Dallman, M.D., McGinty, J. (2017) OPTiM: Optical projection tomography integrated microscope using open-source hardware and software. PLoS One. 12:e0180309
Kumar, S., Lockwood, N., Ramel, M.C., Correia, T., Ellis, M., Alexandrov, Y., Andrews, N., Patel, R., Bugeon, L., Dallman, M.J., Brandner, S., Arridge, S., Katan, M., McGinty, J., Frankel, P., French, P.M. (2016) Quantitative in vivo optical tomography of cancer progression & vasculature development in adult zebrafish. Oncotarget. 7(28):43939-43948
Andrews, N., Ramel, M.C., Kumar, S., Alexandrov, Y., Kelly, D.J., Warren, S.C., Kerry, L., Lockwood, N., Frolov, A., Frankel, P., Bugeon, L., McGinty, J., Dallman, M.J., French, P.M. (2016) Visualising apoptosis in live zebrafish using fluorescence lifetime imaging with optical projection tomography to map FRET biosensor activity in space and time. Journal of biophotonics. 9(4):414-24
Progatzky, F., Cook, H.T., Lamb, J.R., Bugeon, L., Dallman, M.J. (2016) Mucosal inflammation at the respiratory interface: a zebrafish model. American journal of physiology. Lung cellular and molecular physiology. 310(6):L551-61
van Boxtel, A.L., Chesebro, J.E., Heliot, C., Ramel, M.C., Stone, R.K., Hill, C.S. (2015) A Temporal Window for Signal Activation Dictates the Dimensions of a Nodal Signaling Domain. Developmental Cell. 35:175-185
Jones, P.J., Sim, A., Taylor, H.B., Bugeon, L., Dallman, M.J., Pereira, B., Stumpf, M.P., Liepe, J. (2015) Inference of random walk models to describe leukocyte migration. Physical Biology. 12:066001
Correia, T., Lockwood, N., Kumar, S., Yin, J., Ramel, M.C., Andrews, N., Katan, M., Bugeon, L., Dallman, M.J., McGinty, J., Frankel, P., French, P.M., Arridge, S. (2015) Accelerated Optical Projection Tomography Applied to In Vivo Imaging of Zebrafish. PLoS One. 10:e0136213
Broncel, M., Serwa, R.A., Ciepla, P., Krause, E., Dallman, M.J., Magee, A.I., Tate, E.W. (2015) Myristoylation profiling in human cells and zebrafish. Data in brief. 4:379-83
Progatzky, F., Sangha, N.J., Yoshida, N., McBrien, M., Cheung, J., Shia, A., Scott, J., Marchesi, J.R., Lamb, J.R., Bugeon, L., Dallman, M.J. (2014) Dietary cholesterol directly induces acute inflammasome-dependent intestinal inflammation. Nature communications. 5:5864
Ciepla, P., Konitsiotis, A.D., Serwa, R.A., Masumoto, N., Leong, W.P., Dallman, M.J., Magee, A.I., Tate, E.W. (2014) New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish. Chemical science. 5:4249-4259
Ramel, M.C., and Hill, C.S. (2013) The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands. Developmental Biology. 378(2):170-82
Progatzky, F., Dallman, M.J., and Lo Celso, C. (2013) From seeing to believing: labelling strategies for in vivo cell-tracking experiments. Interface Focus. 3(3):20130001
Sanvitale, C.E., Kerr, G., Chaikuad, A., Ramel, M.C., Mohedas, A.H., Reichert, S., Wang, Y., Triffitt, J.T., Cuny, G.D., Yu, P.B., Hill, C.S., and Bullock, A.N. (2013) A New Class of Small Molecule Inhibitor of BMP Signaling. PLoS One. 8(4):e62721
Taylor, H.B., Liepe, J., Barthen, C., Bugeon, L., Huvet, M., Kirk, P.D., Brown, S.B., Lamb, J.R., Stumpf, M.P., and Dallman, M.J. (2013) P38 and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish. Immunology and cell biology. 91(1):60-69
Progatzky, F., Taylor, H., Bugeon, L., Cassidy, S., Radbruch, A., Dallman, M.J., and Lamb, J.R. (2012) The role of Nfil3 in zebrafish hematopoiesis. Developmental and comparative immunology. 38(1):187-192
Chen, L., McGinty, J., Taylor, H.B., Bugeon, L., Lamb, J.R., Dallman, M.J., and French, P.M. (2012) Incorporation of an experimentally determined MTF for spatial frequency filtering and deconvolution during optical projection tomography reconstruction. Optics express. 20(7):7323-7337
Liepe, J., Taylor, H., Barnes, C.P., Huvet, M., Bugeon, L., Thorne, T., Lamb, J.R., Dallman, M.J., and Stumpf, M.P. (2012) Calibrating spatio-temporal models of leukocyte dynamics against in vivo live-imaging data using approximate Bayesian computation. Integrative biology : quantitative biosciences from nano to macro. 4(3):335-345
Bugeon, L., Taylor, H.B., Progatzky, F., Lin, M.I., Ellis, C.D., Welsh, N., Smith, E., Vargesson, N., Gray, C., Renshaw, S.A., Chico, T.J., Zon, L., Lamb, J., and Dallman, M.J. (2011) The NOTCH pathway contributes to cell fate decisions in myelopoiesis. Haematologica. 96(12):1753-60
McGinty, J., Taylor, H.B., Chen, L., Bugeon, L., Lamb, J.R., Dallman, M.J., and French, P.M. (2011) In vivo fluorescence lifetime optical projection tomography. Biomedical Optics Express. 2(5):1340-1350
Wu, M.Y., Ramel, M.C., Howell, M., and Hill, C.S. (2011) SNW1 Is a Critical Regulator of Spatial BMP Activity, Neural Plate Border Formation, and Neural Crest Specification in Vertebrate Embryos. PLoS Biology. 9(2):e1000593