ZFIN ID: ZDB-LAB-111031-1
Gui Lab
PI/Director: Gui, Jian-Fang
Co-PI / Senior
Researcher:
Zhang, Yi-Bing
Zhou, Li
Contact Person: Gui, Jian-Fang
Email: jfgui@ihb.ac.cn
URL: http://sourcedb.cas.cn/sourcedb_ihb_cas/en/expert/pl/200907/t20090722_2156224.html
Address: No. 7 Donghu South Road, Wuchang District, Wuhan, Hubei Province, P.R.China
Country: China
Phone: 86-027-68780707
Fax:
Line Designation: ihb


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 10 genomic features


STATEMENT OF RESEARCH INTERESTS
1. Developmental Genetics: The scientific objectives are to identify reproduction-, and growth- related genes, and thereby to reveal regulation mechanisms on fish gynogenesis and oogenesis, and to investigate temporal and spatial control of gene expression in fish early embryogenesis.

2. Immunological Genetics: The scientific objective is to identify immune-related genes, especially the innate immunity-related genes, and thereby to identify disease-resistant genes and to reveal immunological mechanisms on disease prevention and cure in fish.

3. Fish Genetic Breeding: This study field is looking forward to molecular markers for discriminating different populations or strains, and is trying to apply them to the studies on ecological genetics and selective breeding in aquaculture animals. In addition, the Laboratory is devoted to cell engineering technology in fish, such as genome manipulation, cell fate tracing, and gene knockdown. The target species include gibel carp (Carassius auratus gibelio), goldfish (Carassius auratus), and grouper (Epinephelus coioides), as well as model fish zebrafish (Danio rerio).


LAB MEMBERS
Wang, Yang Wang, Zhong-Wei Wei, Li-Hua
Zhang, Xiao-juan


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS x
Huang, W., Yang, P., Lv, Z., Wu, C., Gui, J., Lou, B. (2017) Cloning, expression pattern and promoter functional analysis of cyp19a1a gene in miiuy croaker. Gene. 627:271-277
Li, S.Z., Liu, W., Li, Z., Li, W.H., Wang, Y., Zhou, L., Gui, J.F. (2017) greb1 regulates convergent extension movement and pituitary development in zebrafish. Gene. 627:176-187
Sun, Z.H., Zhou, L., Li, Z., Liu, X.C., Li, S.S., Wang, Y., Gui, J.F. (2017) Sexual dimorphic expression of dnd in germ cells during sex reversal and its requirement for primordial germ cell survival in protogynous hermaphroditic grouper. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 208-209:47-57
Yang, Y.J., Wang, Y., Li, Z., Zhou, L., Gui, J.F. (2017) Sequential, Divergent and Cooperative Requirements of Foxl2a and Foxl2b in Ovary Development and Maintenance of Zebrafish. Genetics. 205(4):1551-1572
Feng, H., Zhang, Q.M., Zhang, Y.B., Li, Z., Zhang, J., Xiong, Y.W., Wu, M., Gui, J.F. (2016) Zebrafish IRF1, IRF3, and IRF7 Differentially Regulate IFNΦ1 and IFNΦ3 Expression through Assembly of Homo- or Heteroprotein Complexes. Journal of immunology (Baltimore, Md. : 1950). 197(5):1893-904
Jing, J., Xiong, S., Li, Z., Wu, J., Zhou, L., Gui, J.F., Mei, J. (2015) A feedback regulatory loop involving p53/miR-200 and growth hormone endocrine axis controls embryo size of zebrafish. Scientific Reports. 5:15906
Li, W.H., Zhou, L., Li, Z., Wang, Y., Shi, J.T., Yang, Y.J., Gui, J.F. (2015) Zebrafish Lbh-like Is Required for Otx2-mediated Photoreceptor Differentiation. International journal of biological sciences. 11(6):688-700
Mei, J., Gui, J.F. (2015) Genetic basis and biotechnological manipulation of sexual dimorphism and sex determination in fish.. Science China. Life sciences. 58(2):124-36
Wang, Y., Li, W.H., Li, Z., Liu, W., Zhou, L., Gui, J.F. (2015) BMP and RA signaling cooperate to regulate Apolipoprotein C1 expression during embryonic development. Gene. 554:196-204
Chen, T., Zhou, L., Yuan, Y., Fang, Y., Guo, Y., Huang, H., Zhou, Q., Lv, X. (2014) Characterization of Bbx, a member of a novel subfamily of the HMG-box superfamily together with Cic. Development genes and evolution. 224(4-6):261-8
Beck, B.B., Phillips, J.B., Bartram, M.P., Wegner, J., Thoenes, M., Pannes, A., Sampson, J., Heller, R., Göbel, H., Koerber, F., Neugebauer, A., Hedergott, A., Nürnberg, G., Nürnberg, P., Thiele, H., Altmüller, J., Toliat, M.R., Staubach, S., Boycott, K.M., Valente, E.M., Janecke, A.R., Eisenberger, T., Bergmann, C., Tebbe, L., Wang, Y., Wu, Y., Fry, A.M., Westerfield, M., Wolfrum, U., Bolz, H.J. (2014) Mutation of POC1B in a Severe Syndromic Retinal Ciliopathy. Human Mutation. 35(10):1153-62
Xiao, Q., Xia, J.H., Zhang, X.J., Li, Z., Wang, Y., Zhou, L., Gui, J.F. (2014) Type-IV Antifreeze Proteins are Essential for Epiboly and Convergence in Gastrulation of Zebrafish Embryos. International journal of biological sciences. 10:715-32
Zhang, Z., Jia, H., Zhang, Q., Wan, Y., Song, B., Jia, Q., Liu, H., Zhu, X., Fang, X. (2014) Transcriptome analysis of Rpl11-deficient zebrafish model of Diamond-Blackfan Anemia. Genomics Data. 2:173-5
Wang, Y., Sun, Z.H., Zhou, L., Li, Z., Gui, J.F. (2014) Grouper tshbeta Promoter-Driven Transgenic Zebrafish Marks Proximal Kidney Tubule Development. PLoS One. 9:e97806
Zhong, J.X., Zhou, L., Li, Z., Wang, Y., Gui, J.F. (2014) Zebrafish Noxa promotes mitosis in early embryonic development and regulates apoptosis in subsequent embryogenesis. Cell death and differentiation. 21:1013-24
Li, C., Ma, H., Wang, Y., Cao, Z., Graves-Deal, R., Powell, A.E., Starchenko, A., Ayers, G.D., Washington, M.K., Kamath, V., Desai, K., Gerdes, M.J., Solnica-Krezel, L., Coffey, R.J. (2014) Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer. J. Clin. Invest.. 124(5):2172-87
Shi, J., Zhang, Y.B., Zhang, J.S., and Gui, J.F. (2013) Expression regulation of zebrafish interferon regulatory factor 9 by promoter analysis. Developmental and comparative immunology. 41(4):534-543
Wang, Y., Zhou, L., Li, Z., Li, W., and Gui, J. (2013) Apolipoprotein C1 regulates epiboly during gastrulation in zebrafish. Science China. Life sciences. 56(11):975-984
Yue, H.M., Li, Z., Wu, N., Liu, Z., Wang, Y., and Gui, J.F. (2013) Oocyte-Specific H2A Variant H2af1o Is Required for Cell Synchrony Before Mid-Blastula Transition in Early Zebrafish Embryos. Biology of reproduction. 89(4):82
Liu, Y., Zhang, Y.B., Liu, T.K., and Gui, J.F. (2013) Lineage-Specific Expansion of IFIT Gene Family: An Insight into Coevolution with IFN Gene Family. PLoS One. 8(6):e66859
Zhang, Y.B., Liu, T.K., Jiang, J., Shi, J., Liu, Y., Li, S., and Gui, J.F. (2013) Identification of a novel gig2 gene family specific to non-amniote vertebrates. PLoS One. 8(4):e60588
Li, Z., Zheng, W., Wang, Z., Zeng, Z., Zhan, H., Li, C., Zhou, L., Yan, C., Spitsbergen, J.M., and Gong, Z. (2013) An inducible Myc zebrafish liver tumor model revealed conserved Myc signatures with mammalian liver tumors. Disease models & mechanisms. 427(1):223-226
Xie, X., Tan, J., Wei, D., Lei, D., Yin, T., Huang, J., Zhang, X., Qiu, J., Tang, C., and Wang, G. (2013) In vitro and in vivo investigations on the effects of low-density lipoprotein concentration polarization and haemodynamics on atherosclerotic localization in rabbit and zebrafish. Journal of the Royal Society, Interface. 10(82):20121053
Xu, S., Xia, W., Zohar, Y., and Gui, J.F. (2013) Zebrafish dmrta2 Regulates the Expression of cdkn2c in Spermatogenesis in the Adult Testis. Biology of reproduction. 88(1):14
Huang, X., Zhou, L., and Gong, Z. (2012) Liver tumor models in transgenic zebrafish: an alternative in vivo approach to study hepatocarcinogenes. Future oncology (London, England). 8(1):21-28
Li, S., Sun, F., Zhang, Y.B., Gui, J.F., and Zhang, Q.Y. (2012) Identification of DreI as an Antiviral Factor Regulated by RLR Signaling Pathway. PLoS One. 7(3):e32427
Wang, Y., Zhang, W., Wu, Z., Zhu, X., and Lu, C. (2011) Functional analysis of luxS in Streptococcus suis reveals a key role in biofilm formation and virulence. Veterinary Microbiology. 152(1-2):151-60
Gou, M., Men, K., Shi, H., Xiang, M., Zhang, J., Song, J., Long, J., Wan, Y., Luo, F., Zhao, X., and Qian, Z. (2011) Curcumin-loaded biodegradable polymeric micelles for colon cancer therapy in vitro and in vivo. Nanoscale. 3(4):1558-67
Wang, R., Li, Z., Wang, Y., and Gui, J.F. (2011) An apo-14 promoter-driven transgenic zebrafish that marks liver organogenesis. PLoS One. 6(7):e22555
Li, M., Hong, N., Xu, H., Yi, M., Li, C., Gui, J., Hong, Y. (2009) Medaka vasa is required for migration but not survival of primordial germ cells. Mechanisms of Development. 126(5-6):366–381
Yin, J., Xia, J.H., Du, X.Z., Liu, J., Zhou, L., Hong, Y.H., and Gui, J.F. (2007) Developmental expression of CagMdkb during gibel carp embryogenesis. The International journal of developmental biology. 51(8):761-769
Ji, G.D., Zhou, L., Wang, Y., Xia, W., and Gui, J.F. (2006) Identification of a novel C2 domain factor in ovaries of orange-spotted grouper (Epinephelus coioides). Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 143(3):374-383
Wang, Y., Zhou, L., Yao, B., Li, C.J., and Gui, J.F. (2004) Differential expression of thyroid-stimulating hormone beta subunit in gonads during sex reversal of orange-spotted and red-spotted groupers. Molecular and Cellular Endocrinology. 220(1-2):77-88
Zhou, L., and Irwin, D.M. (2004) Fish proglucagon genes have differing coding potential. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 137(2):255-264