ZFIN ID: ZDB-LAB-110914-1
XL Chen Lab
PI/Director: Chen, Xiaoxin Luke
Contact Person: Chen, Hao
Email: yhu@nccu.edu
URL: http://web.nccu.edu/academics/bbri/personnel/chen.htm
Address: Cancer Research Program Julius L. Chambers Biomedical Biotechnology Research Institute North Carolina Central University 700 George St, Durham, NC 27707
Country: United States
Phone: 919-530-7004
Fax: 919-530-7780
Line Designation: ncc


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 2 genomic features


STATEMENT OF RESEARCH INTERESTS
1. Molecular mechanism of intestinal metaplasia in the esophagus (Barrett's esophagus) and chemoprevention of esophageal adenocarcinoma: The goal of this project is to study the roles of gastroesophageal refluxate (acid and bile acids), genetic and epigenetic pathways in the development of Barrett's esophagus, the premalignant lesion of esophageal adenocarcinoma, in cell culture, animal models, and humans. Current studies focus on three areas: (1) How a group of squamous and intestinal transcription factors contribute to intestinal metaplasia in cell culture, surgical models (rats, mice, pigs) and genetically models (zebrafish, pigs). (2) How genetic factors and gene-environment interactions may contribute to racial disparity of Barrett's esophagus, e.g., why Caucasian Americans are more susceptible to Barrett's esophagus than African Amercians. (3) What molecular pathways may regulate resistance properties of esophageal squamous epithelium in the presence of gastroesophageal reflux.

2. Molecular mechanism and chemoprevention of alcohol and tobacco-associated oral cancer: We focus on aberrant arachidonic acid metabolism (especially the 5-lipoxygenase pathway) and oxidative damage in oral carcinogenesis of carcinogen-induced models in hamsters and mice. Both pharmacological (pharmaceutical and dietary agents) and genetic approaches are employed to elucidate the mechanism of oral carcinogenesis and design mechanism-based chemopreventive strategies. Potential candidate agents are further tested in human clinical trials.


LAB MEMBERS
Chen, Hao Post-Doc Beasley, Andrea Graduate Student Hu, Yuhui Research Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Zlatanova, I., Sun, F., Wu, R.S., Chen, X., Lau, B.H., Colombier, P., Sinha, T., Celona, B., Xu, S.M., Materna, S.C., Huang, G.N., Black, B.L. (2023) An injury-responsive mmp14b enhancer is required for heart regeneration. Science advances. 9:eadh5313eadh5313
Fischer, P., Chen, H., Pacho, F., Rieder, D., Kimmel, R.A., Meyer, D. (2019) FoxH1 represses miR-430 during early embryonic development of zebrafish via non-canonical regulation. BMC Biology. 17:61
Huang, J., Liu, X., Chen, H., Chen, L., Gao, X., Pan, Z., Wang, J., Lu, C., Yao, H., Wang, L., Wu, Z. (2019) Identification of six novel capsular polysaccharide loci (NCL) from Streptococcus suis multidrug resistant non-typeable strains and the pathogenic characteristic of strains carrying new NCLs. Transboundary and Emerging diseases. 66(2):995-1003
Huang, X., Chen, H., Shaffer, P.L. (2017) Crystal Structures of Human GlyRα3 Bound to Ivermectin. Structure (London, England : 1993). 25(6):945-950
Filiano, A.J., Xu, Y., Tustison, N.J., Marsh, R.L., Baker, W., Smirnov, I., Overall, C.C., Gadani, S.P., Turner, S.D., Weng, Z., Peerzade, S.N., Chen, H., Lee, K.S., Scott, M.M., Beenhakker, M.P., Litvak, V., Kipnis, J. (2016) Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour. Nature. 535:425-9
Zhang, Y., Zhang, Y., Chen, A., Zhang, W., Chen, H., Zhang, Q. (2016) Enantioselectivity in Developmental Toxicity of rac-metalaxyl and R-metalaxyl in Zebrafish (Danio rerio) Embryo. Chirality. 28(6):489-94
Zhu, Y., Wang, P., Zhao, Y., Yang, C., Clark, A., Leung, T., Chen, X., Sang, S. (2016) Synthesis, Evaluation, and Metabolism of Novel [6]-Shogaol Derivatives as Potent Nrf2 Activators. Free radical biology & medicine. 95:243-54
Chen, H., Beasley, A., Hu, Y., Chen, X. (2015) A Zebrafish Model for Studies on Esophageal Epithelial Biology. PLoS One. 10:e0143878
Chen, H., Babino, D., Schoenbichler, S.A., Arkhipova, V., Töchterle, S., Martin, F., Huck, C.W., von Lintig, J., Meyer, D. (2015) Nmnat1-Rbp7 Is a Conserved Fusion-Protein That Combines NAD+ Catalysis of Nmnat1 with Subcellular Localization of Rbp7. PLoS One. 10:e0143825
Fan, Y.Q., Li, P.H., Chao, Y.X., Chen, H., Du, N., He, Q.X., Liu, K.C. (2015) Alkaloids with Cardiovascular Effects from the Marine-Derived Fungus Penicillium expansum Y32. Marine drugs. 13:6489-6504
Zhang, C., Frazier, J.M., Chen, H., Liu, Y., Lee, J.A., Cole, G.J. (2014) Molecular and morphological changes in zebrafish following transient ethanol exposure during defined developmental stages. Neurotoxicology and teratology. 44:70-80
Chen, W., Zhang, L., Zheng, G., Fu, Y., Ji, Q., Liu, F., Chen, H., He, C. (2014) Crystal structure of the RNA demethylase ALKBH5 from zebrafish. FEBS letters. 588:892-8
Hu, B., Chen, H., Liu, X., Zhang, C., Cole, G.J., Lee, J.A., and Chen, X. (2013) Transgenic Overexpression of cdx1b Induces Metaplastic Changes of Gene Expression in Zebrafish Esophageal Squamous Epithelium. Zebrafish. 10(2):218-227
Li, Q., Zhou, X., Guo, Y., Shang, X., Chen, H., Lu, H., Cheng, H., and Zhou, R. (2008) Nuclear localization, DNA binding and restricted expression in neural and germ cells of zebrafish Dmrt3. Biology of the cell. 100(8):453-463
Xu, H., Yang, J., Wang, Y., Jiang, Q., Chen, H., and Song, H. (2008) Exposure to 17α-ethynylestradiol impairs reproductive functions of both male and female zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 88(1):1-8
Zhou, X., Li, Q., Lu, H., Chen, H., Guo, Y., Cheng, H., and Zhou, R. (2008) Fish specific duplication of Dmrt2: Characterization of zebrafish Dmrt2b. Biochimie. 90(6):878-887
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