ZFIN ID: ZDB-LAB-081125-1
Frazer Lab
PI/Director: Frazer, Kimble
Contact Person: Frazer, Kimble
Email: Kimble-frazer@ouhsc.edu
URL:
Address: Frazer Laboratory University of Oklahoma Health Sciences Center Basic Sciences Education Bldg., Rm. 229 Oklahoma City, OK 73104
Country: United States
Phone: 405-271-5311 ext. 42375
Fax: 405-271-3767
Line Designation: None assigned


GENOMIC FEATURES ORIGINATING FROM THIS LABNo data available


STATEMENT OF RESEARCH INTERESTS
Our lab studies 2 related types of T cell cancer: T cell acute lymphoblastic leukemia (T-ALL) and T cell lymphoblastic lymphoma (T-LBL). We use several T cell cancer-prone genetic lines to investigate the genomic, genetic, and transcriptional events that underlie oncogenesis. We also pursue the molecular explanations for why some T cell cancers are more aggressive and/or drug-resistant than others. Finally, we use fish with active cancers to test candidate compounds in vivo, to see whether they might be effective medicines for the treatment of T cell malignancy.


LAB MEMBERS
Batchelor, Lance Research Staff Squiban, Barbara Research Staff Hawkins, Julie Technical Staff
Schatzman-Bone, Steph Technical Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS x
Nissim, S., Weeksb, O., Talbot, J.C., Hedgepeth, J.W., Wucherpfennig, J., Schatzman-Bone, S., Swinburne, I., Cortes, M., Alexa, K., Megason, S., North, T.E., Amacher, S.L., Goessling, W. (2016) Iterative use of nuclear receptor Nr5a2 regulates multiple stages of liver and pancreas development. Developmental Biology. 418(1):108-23
Jain, I.H., Zazzeron, L., Goli, R., Alexa, K., Schatzman-Bone, S., Dhillon, H., Goldberger, O., Peng, J., Shalem, O., Sanjana, N.E., Zhang, F., Goessling, W., Zapol, W.M., Mootha, V.K. (2016) Hypoxia as a therapy for mitochondrial disease. Science (New York, N.Y.). 352(6281):54-61
Liu, L.Y., Alexa, K., Cortes, M., Schatzman-Bone, S., Kim, A.J., Mukhopadhyay, B., Cinar, R., Kunos, G., North, T.E., Goessling, W. (2016) Cannabinoid receptor signaling regulates liver development and metabolism. Development (Cambridge, England). 143:609-22
Squiban, B., Frazer, J.K. (2014) Danio rerio: Small Fish Making a Big Splash in Leukemia. Current pathobiology reports. 2:61-73
West, K., Miles, R., Kent, M.L., Frazer, J.K. (2014) Unusual Fluorescent Granulomas and Myonecrosis in Danio Rerio Infected by the Microsporidian Pathogen Pseudoloma Neurophilia. Zebrafish. 11(3):283-90
Christoph, S., Deryckere, D., Schlegel, J., Frazer, J.K., Batchelor, L.A., Trakhimets, A.Y., Sather, S., Hunter, D.M., Cummings, C., Liu, J., Yang, C., Kireev, D., Simpson, C., Norris-Drouin, J., Hull-Ryde, E.A., Janzen, W.P., Johnson, G.L., Wang, X., Frye, S.V., Earp, H.S., and Graham, D.K. (2013) UNC569, a novel small molecule Mer inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo. Molecular cancer therapeutics. 12(11):2367-77
Ridges, S., Heaton, W.L., Joshi, D., Choi, H., Eiring, A., Batchelor, L., Choudhry, P., Manos, E.J, Sofla, H., Sanati, A., Welborn, S., Agarwal, A., Spangrude, G.J., Miles, R.R., Cox, J.E., Frazer, J.K., Deininger, M., Balan, K., Sigman, M., Müschen, M., Perova, T., Johnson, R., Montpellier, B., Guidos, C.J., Jones, D.A., and Trede, N.S. (2012) Zebrafish screen identifies novel compound with selective toxicity against leukemia. Blood. 119(24):5621-5631
Frazer, J.K., Batchelor, L.A., Bradley, D.F., Brown, K.H., Dobrinski, K.P., Lee, C., and Trede, N.S. (2012) Genomic Amplification of an Endogenous Retrovirus in Zebrafish T-Cell Malignancies. Advances in hematology. 2012:627920
Rudner, L.A., Brown, K.H., Dobrinski, K.P., Bradley, D.F., Garcia, M.I., Smith, A.C., Downie, J.M., Meeker, N.D., Look, A.T., Downing, J.R., Gutierrez, A., Mullighan, C.G., Schiffman, J.D., Lee, C., Trede, N.S., and Frazer, J.K. (2011) Shared acquired genomic changes in zebrafish and human T-ALL. Oncogene. 30(41):4289-96
Meeker, N.D., Smith, A.C., Frazer, J.K., Bradley, D.F., Rudner, L.A., Love, C., and Trede, N.S. (2010) Characterization of the zebrafish T cell receptor beta locus. Immunogenetics. 62(1):23-29
Frazer, J.K., Meeker, N.D., Rudner, L., Bradley, D.F., Smith, A.C., Demarest, B., Joshi, D., Locke, E.E., Hutchinson, S.A., Tripp, S., Perkins, S.L., and Trede, N.S. (2009) Heritable T-cell malignancy models established in a zebrafish phenotypic screen. Leukemia. 23(10):1825-1835
Rudner, L.A., Frazer, J.K., and Trede, N.S. (2009) Modeling human hematologic malignancies in zebrafish: A review. Current Trends in Immunology. 10:119-124