ZFIN ID: ZDB-LAB-060317-1
Torres-Vazquez Lab
PI/Director: Torres-Vazquez, Jesus
Contact Person: Torres-Vazquez, Jesus
Email: Jesus.Torres-Vazquez@med.nyu.edu
URL: http://skirball.med.nyu.edu/faculty/az/jesus-torres-vazquez
Address: Kimmel Center for Biology and Medicine of the Skirball Institute New York University School of Medicine 540 First Avenue 4th Floor, Lab 14 New York, NY 10016
Country: United States
Phone: (212) 263-0259 Office
Fax: (212) 263-7760
Line Designation: skt

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Formation, remodeling and function of the vascular system using zebrafish and cultured cells as model systems. Our studies focus on these areas.
1. Patterning of angiogenic development
2. Vascularization of the central nervous system (CNS) and blood-brain barrier (BBB) differentiation
3. Mechanisms of vessel assembly and lumenization

Carretero-Ortega, Jorge Post-Doc Menendez Gonzalez, Javier Post-Doc Chhangawala, Zinal Technical Staff
Hunt, Shane Technical Staff Narvaez, Carlos Technical Staff Grosso, John Administrative Staff

Carretero-Ortega, J., Chhangawala, Z., Hunt, S., Narvaez, C., Menéndez-González, J., Gay, C.M., Zygmunt, T., Li, X., Torres-Vázquez, J. (2019) GIPC proteins negatively modulate Plexind1 signaling during vascular development. eLIFE. 8:
Ulrich, F., Grove, C., Torres-Vázquez, J., Baker, R. (2016) Development of functional hindbrain oculomotor circuitry independent of both vascularization and neuronal activity in larval zebrafish. Current Neurobiology. 7:62-73
Ulrich, F., Carretero-Ortega, J., Menéndez, J., Narvaez, C., Sun, B., Lancaster, E., Pershad, V., Trzaska, S., Véliz, E., Kamei, M., Prendergast, A., Kidd, K.R., Shaw, K.M., Castranova, D.A., Pham, V.N., Lo, B.D., Martin, B.L., Raible, D.W., Weinstein, B.M., Torres-Vazquez, J. (2016) Reck enables cerebrovascular development by promoting canonical Wnt signaling. Development (Cambridge, England). 143(1):147-59
Nagelberg, D., Wang, J., Su, R., Torres-Vazquez, J., Targoff, K.L., Poss, K.D., Knaut, H. (2015) Origin, specification and plasticity of the great vessels of the heart.. Current biology : CB. 25:2099-2110
Minchin, J.E., Dahlman, I., Harvey, C.J., Mejhert, N., Singh, M.K., Epstein, J.A., Arner, P., Torres-Vazquez, J., Rawls, J.F. (2015) Plexin D1 determines body fat distribution by regulating the type V collagen microenvironment in visceral adipose tissue. Proceedings of the National Academy of Sciences of the United States of America. 112(14):4363-8
Fang, F., Wasserman, S.M., Torres-Vazquez, J., Weinstein, B., Cao, F., Li, Z., Wilson, K.D., Yue, W., Wu, J.C., Xie, X., and Pei, X. (2014) The role of Hath6, a novel shear stress-responsive transcription factor, in endothelial differentiation and function modulation. Journal of Cell Science. 127(Pt 7):1428-40
Mandal, A., Rydeen, A., Anderson, J., Sorrell, M.R., Zygmunt, T., Torres-Vazquez, J., and Waxman, J.S. (2013) Transgenic retinoic acid sensor lines in zebrafish indicate regions of available embryonic retinoic acid. Developmental dynamics : an official publication of the American Association of Anatomists. 242(8):989-1000
Mendelson, K., Zygmunt, T., Torres-Vazquez, J., Evans, T., and Hla, T. (2013) Sphingosine-1-Phosphate Receptors S1pr1 and S1pr2 Cooperatively Regulate Embryonic Vascular Development. The Journal of biological chemistry. 288(4):2143-2156
Zygmunt, T., Trzaska, S., Edelstein, L., Walls, J., Rajamani, S., Gale, N., Daroles, L., Ramírez, C., Ulrich, F., and Torres-Vazquez, J. (2012) In parallel interconnectivity of the dorsal longitudinal anastomotic vessels requires both VEGF signaling and circulatory flow. Journal of Cell Science. 125(21):5159-5167
Pan, W., Pham, V.N., Stratman, A.N., Castranova, D., Kamei, M., Kidd, K.R., Lo, B.D., Shaw, K.M., Torres-Vazquez, J., Mikelis, C.M., Gutkind, J.S., Davis, G.E., and Weinstein, B.M. (2012) CDP-diacylglycerol synthetase-controlled phosphoinositide availability limits VEGFA signaling and vascular morphogenesis. Blood. 120(2):489-498
Totong, R., Schell, T., Lescroart, F., Ryckebüsch, L., Lin, Y.F., Zygmunt, T., Herwig, L., Krudewig, A., Gershoony, D., Belting, H.G., Affolter, M., Torres-Vazquez, J., and Yelon, D. (2011) The novel transmembrane protein Tmem2 is essential for coordination of myocardial and endocardial morphogenesis. Development (Cambridge, England). 138(19):4199-4205
Ulrich, F., Ma, L.H., Baker, R.G., and Torres-Vazquez, J. (2011) Neurovascular development in the embryonic zebrafish hindbrain. Developmental Biology. 357(1):134-51
Zygmunt, T., Gay, C.M., Blondelle, J., Singh, M.K., Flaherty, K.M., Means, P.C., Herwig, L., Krudewig, A., Belting, H.G., Affolter, M., Epstein, J.A., and Torres-Vazquez, J. (2011) Semaphorin-PlexinD1 Signaling Limits Angiogenic Potential via the VEGF Decoy Receptor sFlt1. Developmental Cell. 21(2):301-314
Gay, C.M., Zygmunt, T., and Torres-Vazquez, J. (2011) Diverse functions for the semaphorin receptor PlexinD1 in development and disease. Developmental Biology. 349(1):1-19
Alvarez, Y., Cederlund, M.L., Cottell, D.C., Bill, B.R., Ekker, S.C., Torres-Vazquez, J., Weinstein, B.M., Hyde, D.R., Vihtelic, T.S., and Kennedy, B.N. (2007) Genetic determinants of hyaloid and retinal vasculature in zebrafish. BMC Developmental Biology. 7(1):114
Shaw, K.M., Castranova, D.A., Pham, V.N., Kamei, M., Kidd, K.R., Lo, B.D., Torres-Vazquez, J., Ruby, A., and Weinstein, B.M. (2006) fused-somites-like mutants exhibit defects in trunk vessel patterning. Developmental dynamics : an official publication of the American Association of Anatomists. 235(7):1753-1760
Torres-Vazquez, J., Gitler, A.D., Fraser, S.D., Berk, J.D., Pham, V.N., Fishman, M.C., Childs, S., Epstein, J.A., and Weinstein, B.M. (2004) Semaphorin-plexin signaling guides patterning of the developing vasculature. Developmental Cell. 7(1):117-123
Kamei, M., Kidd, K.R., Torres-Vazquez, J., and Weinstein, B.M. (2004) Making waves in Madison: the 6th International Meeting on Zebrafish Development and Genetics. Zebrafish. 1(2):145-163
Torres-Vazquez, J., Kamei, M., and Weinstein, B.M. (2003) Molecular distinction between arteries and veins. Cell and tissue research. 314(1):43-59