ZFIN ID: ZDB-LAB-000218-3
Nigel Holder Lab
PI/Director: Holder, Nigel
Contact Person:
Email: ucgadob@ucl.ac.uk
URL: http://www.ucl.ac.uk/zebrafish-group/
Address: Department of Anatomy and Developmental Biology University College London Gower Street London WC1E 6BT UNITED KINGDOM
Country: United Kingdom
Phone: 44-207-679-3330
Fax: 44-207-679-7349
Line Designation: None assigned


GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available


STATEMENT OF RESEARCH INTERESTS


LAB MEMBERS


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Hawkins, T.A., Haramis, A.P., Etard, C., Prodromou, C., Vaughan, C.K., Ashworth, R., Ray, S., Behra, M., Holder, N., Talbot, W.S., Pearl, L.H., Strähle, U., and Wilson, S.W. (2008) The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis. Development (Cambridge, England). 135(6):1147-1156
Holder, N., and Xu, Q. (2008) The zebrafish: an overview of its early development. Methods in molecular biology (Clifton, N.J.). 461:483-491
Teraoka, H., Russell, C., Regan, J., Chandrasekhar, A., Concha, M.L., Yokoyama, R., Higashi, K., Take-Uchi, M., Dong, W., Hiraga, T., Holder, N., and Wilson, S.W. (2004) Hedgehog and Fgf signaling pathways regulate the development of tphR-expressing serotonergic raphe neurons in zebrafish embryos. Journal of neurobiology. 60(3):275-288
Barrios, A., Poole, R.J., Durbin, L., Brennan, C., Holder, N., and Wilson, S.W. (2003) Eph/Ephrin signaling regulates the mesenchymal-to-epithelial transition of the paraxial mesoderm during somite morphogenesis. Current biology : CB. 13(18):1571-1582
Grandel, H., Lun, K., Rauch, G.J., Rhinn, M., Piotrowski, T., Houart, C., Sordino, P., Küchler, A.M., Schulte-Merker, S., Geisler, R., Holder, N., Wilson, S.W., and Brand, M. (2002) Retinoic acid signalling in the zebrafish embryo is necessary during pre-segmentation stages to pattern the anterior-posterior axis of the CNS and to induce a pectoral fin bud. Development (Cambridge, England). 129(12):2851-2865
Cooke, J.E., Moens, C.B., Roth, L.W., Durbin, L., Shiomi, K., Brennan, C., Kimmel, C.B., Wilson, S.W., and Holder, N. (2001) Eph signalling functions downstream of Val to regulate cell sorting and boundary formation in the caudal hindbrain. Development (Cambridge, England). 128(4):571-580
Williams, J.A., Barrios, A., Gatchalian, C., Rubin, L., Wilson, S.W., and Holder, N. (2000) Programmed cell death in zebrafish Rohon Beard neurons is influenced by TrkC1/NT-3 signaling. Developmental Biology. 226(2):220-230
Williams, J.A. and Holder, N. (2000) Cell turnover in neuromasts of zebrafish larvae. Hearing Research. 143(1-2):171-81
Durbin, L., Sordino, P., Barrios, A., Gering, M., Thisse, C., Thisse, B., Brennan, C., Green, A., Wilson, S., and Holder, N. (2000) Anteroposterior patterning is required within segments for somite boundary formation in developing zebrafish. Development (Cambridge, England). 127(8):1703-1713
Reiter, J.F., Alexander, J., Rodaway, A., Yelon, D., Patient, R., Holder, N., and Stainier, D.Y. (1999) Gata5 is required for the development of the heart and endoderm in zebrafish. Genes & Development. 13(22):2983-2995
Picker, A., Brennan, C., Reifers, F., Clarke, J.D., Holder, N., and Brand, M. (1999) Requirement for the zebrafish mid-hindbrain boundary in midbrain polarisation, mapping and confinement of the retinotectal projection. Development (Cambridge, England). 126(13):2967-2978
Rodaway, A., Takeda, H., Koshida, S., Broadbent, J., Price, B., Smith, J.C., Patient, R., and Holder, N. (1999) Induction of the mesendoderm in the zebrafish germ ring by yolk cell-derived TGF-ß; family signals and discrimination of mesoderm and endoderm by FGF. Development (Cambridge, England). 126(14):3067-3078
Holder, N., and Klein, R. (1999) Eph receptors and ephrins: effectors of morphogenesis. Development (Cambridge, England). 126(10):2033-2044
Oates, A.C., Lackmann, M., Power, M.A., Brennan, C., Smith, F.M., Do, C., Evans, B., Holder, N., and Boyd, A.W. (1999) An early developmental role for Eph-ephrin interaction during vertebrate gastrulation. Mechanisms of Development. 83(1-2):77-94
Holder, N. and Xu, Q. (1999) Microinjection of DNA, RNA, and protein into the fertilized zebrafish egg for analysis of gene function. Methods in molecular biology (Clifton, N.J.). 97:487-490
Holder, N. and Xu, Q. (1999) The zebrafish. An overview of its early development. Methods in molecular biology (Clifton, N.J.). 97:431-439
Durbin, L., Brennan, C., Shiomi, K., Cooke, J., Barrios, A., Shanmugalingam, S., Guthrie, B., Lindberg, R., and Holder, N. (1998) Eph signaling is required for segmentation and differentiation of the somites. Genes & Development. 12:3096-3109
Read, E.M., Rodaway, A.R., Neave, B., Brandon, N., Holder, N., Patient, R.K., and Walmsley, M.E. (1998) Evidence for non-axial A/P patterning in the nonneural ectoderm of Xenopus and zebrafish pregastrula embryos. The International journal of developmental biology. 42:763-774
Wilson, S.W., C. Brennan, Macdonald, R., M. Brand, and N. Holder (1997) Analysis of axon tract formation in the zebrafish brain: the role of territories of gene expression and their boundaries. Cell and tissue research. 290(2):189-196
Macdonald, R., Scholes, J., Strähle, U., Brennan, C., Holder, N., Brand, M., and Wilson, S.W. (1997) The Pax protein Noi is required for commissural axon pathway formation in the rostral forebrain. Development (Cambridge, England). 124(12):2397-2408
Cooke, J.E., Xu, Q.L., Wilson, S.W., and Holder, N. (1997) Characterisation of five novel zebrafish Eph-related receptor tyrosine kinases suggests roles in patterning the neural plate. Development genes and evolution. 206:515-531
Neave, B., Holder, N., and Patient, R. (1997) A graded response to BMP-4 spatially coordinates patterning of the mesoderm and ectoderm in the zebrafish. Mechanisms of Development. 62(2):183-195
Marcos-Gutiérrez, C.V., Wilson, S.W., Holder, N., and Pachnis, V. (1997) The zebrafish homologue of the ret receptor and its pattern of expression during embryogenesis. Oncogene. 14(8):879-889
Brennan, C., Monschau, B., Lindberg, R., Guthrie, B., Drescher, U., Bonhoeffer, F., and Holder, N. (1997) Two Eph receptor tyrosine kinase ligands control axon growth and may be involved in the creation of the retinotectal map in the zebrafish. Development (Cambridge, England). 124(3):655-664
Holder, N. and McMahon, A. (1996) Genes from zebrafish screens. Nature. 384(6609):515-516
Xu, Q.L., Alldus, G., Macdonald, R., Wilkinson, D.G., and Holder, N. (1996) Function of the Eph-related kinase rtk1 in patterning of the zebrafish forebrain. Nature. 381:319-322
Alexandre, D., Clarke, J.D.W., Oxtoby, E., Yan, Y.L., Jowett, T., and Holder, N. (1996) Ectopic expression of Hoxa-1 in the zebrafish alters the fate of the mandibular arch neural crest and phenocopies a retinoic acid-induced phenotype. Development (Cambridge, England). 122(3):735-746
Costaridis, P., Horton, C., Zeitlinger, J., Holder, N., and Maden, M. (1996) Endogenous retinoids in the zebrafish embryo and adult. Developmental Dynamics : an official publication of the American Association of Anatomists. 205:41-51
Holder, N. (1996) Abstracts of papers presented at the 1996 meeting on zebrafish development & genetics, April 24 - April 26, 1996. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory. :236 p
Holder, N., Brennan, C., Cooke, J., Durbin, L., and Qiling, X. (1996) The role of signalling through Eph receptors in patterning the zebrafish neural plate. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 14:59
Xu, Q.L., Alldus, G., Holder, N., and Wilkinson, D.G. (1995) Expression of truncated Sek-1 receptor tyrosine kinase disrupts the segmental restriction of gene expression in the Xenopus and zebrafish hindbrain. Development (Cambridge, England). 121:4005-4016
Macdonald, R., Barth, K.A., Xu, Q.L., Holder, N., Mikkola, I., and Wilson, S.W. (1995) Midline signalling is required for Pax gene regulation and patterning of the eyes. Development (Cambridge, England). 121:3267-3278
Griffin, K., Patient, R., and Holder, N. (1995) Analysis of FGF function in normal and no tail zebrafish embryos reveals separate mechanisms for formation of the trunk and the tail. Development (Cambridge, England). 121:2983-2994
Neave, B., Rodaway, A., Wilson, S.W., Patient, R., and Holder, N. (1995) Expression of zebrafish GATA 3 (gta3) during gastrulation and neurulation suggests a role in the specification of cell fate. Mechanisms of Development. 51:169-182
Hill, J., Clarke, J.D.W., Vargesson, N., Jowett, T., and Holder, N. (1995) Exogenous retinoic acid causes specific alterations in the development of the midbrain and hindbrain of the zebrafish embryo including positional respecification of the Mauthner neuron. Mechanisms of Development. 50:3-16
Macdonald, R., Xu, Q., Barth, K.A., Mikkola, I., Holder, N., Fjose, A., Krauss, S., and Wilson, S.W. (1994) Regulatory gene expression boundaries demarcate sites of neuronal differentiation in the embryonic zebrafish forebrain. Neuron. 13:1039-1053
Xu, Q., Holder, N., Patient, R., and Wilson, S.W. (1994) Spatially regulated expression of three receptor tyrosine kinase genes during gastrulation in the zebrafish. Development (Cambridge, England). 120:287-299
Krauss, S., Maden, M., Holder, N., and Wilson, S.W. (1992) Zebrafish pax[b] is involved in the formation of the midbrain-hindbrain boundary. Nature. 360:87-89
Holder, N. and Hill, J. (1991) Retinoic acid modifies development of the midbrain-hindbrain border and affects cranial ganglion formation in zebrafish embryos. Development (Cambridge, England). 113:1159-1170
Maden, M. and Holder, N. (1991) The involvement of retinoic acid in the development of the vertebrate central nervous system. Cambridge, The Company of Biologists, Ltd.. Suppl 2:87-94
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