nonsense-mediated decay complex

Term ID

GO:0170010

Synonyms

• Upf complex

Definition

A highly conserved protein complex that recognises and elicits the rapid degradation of mRNAs in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction. (3)

References

• IntAct:EBI-16420380

Ontology

GO: Cellular Component    QuickGO    AmiGO