target-directed miRNA degradation

Term ID

GO:0140958

Synonyms

• target-directed microRNA degradation
• TDMD

Definition

The process in which a miRNA is targeted for degradation by a non-coding RNA or mRNA. The binding of an RNA to a target miRNA within a RISC complex results in either ubiquitin-mediated degradation of AGO protein or the displacement of the 3' end of the miRNA, exposing it to nucleases. (2)

References

Ontology

GO: Biological Process    QuickGO    AmiGO