GAIT complex

Term ID

GO:0097452

Synonyms

• gamma interferon-activated inhibitor of translation complex
• IFN-gamma-activated inhibitor of translation complex

Definition

A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP. (2)

References

Ontology

GO: Cellular Component    QuickGO    AmiGO