hypoxia-inducible factor-1alpha signaling pathway

Term ID

GO:0097411

Synonyms

HIF1alpha pathway
hypoxia-inducible factor signaling
hypoxia-inducible factor-1alpha signalling pathway

Definition

The series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia. http://www.sabiosciences.com/pathway.php?sn=HIF1Alpha_Pathway

References

Ontology

GO: Biological Process QuickGO AmiGO

Relationships

is part of: cellular response to hypoxia

cellular response to hypoxia Show first 5 Terms
is a type of: signal transduction

signal transduction Show first 5 Terms
negatively regulated by: negative regulation of hypoxia-inducible factor-1alpha signaling pathway

negative regulation of hypoxia-inducible factor-1alpha signaling pathway Show first 5 Terms
positively regulated by: positive regulation of hypoxia-inducible factor-1alpha signaling pathway

positive regulation of hypoxia-inducible factor-1alpha signaling pathway Show first 5 Terms
regulated by: regulation of hypoxia-inducible factor-1alpha signaling pathway

regulation of hypoxia-inducible factor-1alpha signaling pathway Show first 5 Terms

Phenotype

Phenotype caused by Genes

Citations