interferon regulatory factor complex

Term ID

GO:0097071

Synonyms

IRF complex

Definition

A protein complex that consists of two interferon regulatory proteins (IRFs); may be homodimeric or heterodimeric. The activation of a latent closed conformation of IRF in the cytoplasm is triggered by phosphorylation of Ser/Thr residues in a C-terminal region. Phosphorylation stimulates the C-terminal autoinhibitory domain to attain a highly extended conformation triggering dimerization through extensive contacts to a second subunit. 20043992

References

Ontology

GO: Cellular Component QuickGO AmiGO

Relationships

is a type of: protein-containing complex

protein-containing complex Show first 5 Terms
has subtype: interferon regulatory factor 3 complex interferon regulatory factor 3-interferon regulatory factor 5 complex interferon regulatory factor 3-interferon regulatory factor 7 complex interferon regulatory factor 5 complex interferon regulatory factor 7 complex

interferon regulatory factor 3 complex interferon regulatory factor 3-interferon regulatory factor 5 complex interferon regulatory factor 3-interferon regulatory factor 7 complex interferon regulatory factor 5 complex interferon regulatory factor 7 complex Show first 5 Terms

Phenotype

Phenotype caused by Genes

Citations