methotrexate binding

Term ID

GO:0051870

Synonyms

Definition

Binding to methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.

References

Ontology

GO: Molecular Function QuickGO AmiGO

Relationships

is a type of: amide binding carboxylic acid binding heterocyclic compound binding organic cyclic compound binding

amide binding carboxylic acid binding heterocyclic compound binding organic cyclic compound binding Show first 5 Terms

Phenotype

Phenotype caused by Genes

Citations