cholate-CoA ligase activity

Term ID

GO:0047747

Synonyms

• 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate--CoA ligase activity
• 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate-CoA ligase activity
• 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate:CoA ligase (AMP-forming) activity
• 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA ligase activity
• 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA synthetase activity
• 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl coenzyme A synthetase activity
• 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate-CoA ligase activity
• 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)
• 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase activity
• 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase activity
• 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase activity
• BAL activity
• bile acid CoA ligase activity
• bile acid coenzyme A ligase activity
• cholate thiokinase activity
• cholate:CoA ligase (AMP-forming)
• cholic acid:CoA ligase activity
• cholic thiokinase activity
• choloyl coenzyme A synthetase activity
• choloyl-CoA synthetase activity
• cholyl-CoA synthetase activity
• THCA-CoA ligase activity
• trihydroxycoprostanoyl-CoA synthetase activity

Definition

Catalysis of the reactions: (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA and (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA. This reaction is the first step in the conjugation of bile acids with amino acids, converting bile acids into their acyl-CoA thioesters. Chenodeoxycholate, deoxycholate, lithocholate and trihydroxycoprostanoate can also act as substrates. 6.2.1.7

References

• EC:6.2.1.7
• MetaCyc:CHOLATE--COA-LIGASE-RXN

Ontology

GO: Molecular Function    QuickGO    AmiGO