symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I

Term ID

GO:0046776

Synonyms

• inhibition of host MHC class I molecule presentation by virus
• negative regulation by virus of MHC class I cell surface presentation
• suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I
• suppression by virus of host MHC class I cell surface presentation
• suppression by virus of host tapasin activity
• suppression by virus of MHC class I cell surface presentation in host

Definition

A process by which a symbiont inhibits or disrupts the normal processing and presentation of a peptide antigen on its cell surface in association with an MHC class I transmembrane protein complex. One mechanism of suppression is by direct inhibition of host tapasin, a type I transmembrane protein essential for the optimal expression of stable MHC class I molecules on the host cell surface. By inhibiting host tapasin activity, some viruses can prevent presentation of their antigens at the cell surface, and thereby evade the host anti-viral immune response. (3)

References

Ontology

GO: Biological Process    QuickGO    AmiGO