error-prone translesion synthesis

Term ID

GO:0042276

Synonyms

• error-prone postreplication DNA repair
• mutagenic postreplication DNA repair
• mutagenic PRR

Definition

The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites. 11485998

References

Ontology

GO: Biological Process    QuickGO    AmiGO